Browsing by Author "Balogun, M.E.,"
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Item Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats(Society for the Conservation of Phytofuels and Sciences., 2022) Ayinde, T.O.,; Ojulari, L.S.,; Afodun, A.M.,; Balogun, M.E.,; Faramade, A.A.,; Raji, A.O.,; Liadi, M.T.,; Belewu, M.A.Caffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.Item Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats.(Society for the Conservation of Phytofuels and Sciences., 2022) Ayinde, T.O.,; Ojulari, L.S.,; Afodun, A.M.,; Balogun, M.E.,; Faramade, A.A.,; Raji, A.O.,; Liadi, M.T.,; Belewu, M.A.Caffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.Item Effect of jatropha curcas seed aqueous extract on quality of semen and reproductive hormones in male Wistar rats(Society of Basic and Applied Physiology, 2022) Ayinde, T.O.,; Abubakar, H.O.,; Ojulari, L.S.,; Balogun, M.E.,; Liadi, M.T.,; Olayaki, L.A.,; Belewu, M.A.,; Afodun, A.MBackground: Jatropha curcas is gaining popularity in recent times due to its medicinal value but with less regards to its adverse health effect especially as it concerns male infertility. The current study was aimed at investigating the effect of Jatropha curcas seed extract on quality of semen and reproductive hormones in male Wistar rats. Methodology: Twenty-four male Wistar rats were randomly divided into four groups of six rats each. Group I served as control and was given 0.9% normal saline, while groups II, III and IV were administered 100, 200 and 400mg/kg of the extracts respectively for 60 days. The rats were then euthanised and blood samples collected via cardiac puncture for testosterone, LH and FSH assay; and semen collected for seminal fluid analysis. Results: There was significant (p<0.05) decrease in sperm count, significant (p<0.05) increase in total sperm abnormality, and significant (p<0.05) increase in sperm motility only at high dose when compared with the control. There was also significant (p<0.05) reduction in testosterone and FSH, while LH showed significant (p<0.05) increase. Conclusion: Jatropha curcas seed extract severed sperm quality with affectation of male reproductive hormones. Thus, male desirous of having babies should exercise caution in its patronage.Item Ethanolic Extract of Nauclea latifolia (African Peach) Protects Against Ethanol-Induced Gastric Mucosal Injury in Rats.(Faculty of Health Sciences, Al-Hikmah University, 2021) Balogun, M.E.,; Ayinde, T.O.,; Oluwasola, A.,; Busari, A.O.,; Ajibola, K.A.; Abubakar, M.MNauclea latifolia is widely used in folk medicine in Nigeria and some West African countries. In vivo study was conducted to investigate the gastroprotective effects of ethanolic leaf extract of N. latifolia (EENL) on ethanol-induced gastric ulcerated rats. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric secretion parameters and ulcerated areas were assessed. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal ulceration. Conclusion: The study suggests that EENL has a protective action against gastric ulcers induced by ethanol in Wistar rats. The protective effect might be mediated via antisecretory and cytoprotective mechanisms.Item Nauclea Latifolia (African Peach) Attenuates Gastric Acid Secretion in Rats with Ethanol-Induced Ulceration(Faculty of Health Sciences, Al-Hikmah University, 2021) Balogun, M.E.,; Umahi, G.O.,; Ayinde, T.O.,; Oluwasola, A.,; Busari, A.O.,; Ajibola, K.A.,; Yusuf, R.O.; Ojulari, L.SItem Tetracarpidium Conophorum (African Walnut): A Review of Pharmaceutical Evidence on Cardiac Toxicity(Faculty of Health Sciences, Al-Hikmah University, 2023) Balogun, M.E.,; Manzuma, A.O.,; Ayinde, T.O.,; Folami, S.O.The ethanolic leaf extract of N. latifolia (EENL) was investigated for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric acid secretion parameters and ulcerated areas were evaluated. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume, total acidity and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal injuries. Conclusion: The study suggests that EENL attenuates gastric acid secretion and ulceration induced by ethanol in Wistar rat. The observed pharmacological activities might be mediated via antisecretory and cytoprotective mechanisms.