Tetracarpidium Conophorum (African Walnut): A Review of Pharmaceutical Evidence on Cardiac Toxicity
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Faculty of Health Sciences, Al-Hikmah University
Abstract
The ethanolic leaf extract of N. latifolia (EENL) was investigated
for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated
rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced
experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were
orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as
ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg
of EENL as the test groups, respectively before ulcer induction. Gastric acid
secretion parameters and ulcerated areas were evaluated. Results:
Pretreatment with EENL showed significant (P < 0.05) reduction in gastric
volume, total acidity and ulcer index while the pH of gastric content increased
significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group
exhibited significantly severe mucosal injury and EENL or omeprazole
offered significant (P < 0.05) protection against gastric mucosal injuries.
Conclusion: The study suggests that EENL attenuates gastric acid secretion
and ulceration induced by ethanol in Wistar rat. The observed
pharmacological activities might be mediated via antisecretory and
cytoprotective mechanisms.
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Citation
Nauclea latifolia, Antacid, Antisecretory, Ethanol, Gastric ulcers, Rats