Browsing by Author "Ayinde, T. O."

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    ABO/Rhesus blood group systems are not clinical indicators of male baldness
    (College of Medicine, Ambrose Alli University, Edo, Nigeria, 2017-06) Ayinde, T. O.; Ojulari, L. S.; Sanni, M. A.; Afodun, A. M.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ayinla, M. T.; Abdulazeez, F. I.; Abdulkareem, S.; Abdulraheem, H. A.; Samotu, K.
    Background: Several disease entities have been linked to the ABO/Rh blood group systems.Baldness or alopecia is the partial or complete lack of hair on the head and/or body. Major advances have been achieved in understanding principal elements of the androgen metabolism involved in the pathogenesis of alopecia, but not much preliminary work has been done in its relationship to blood types. Aim: This study is aimed to determine if there is any association between blood types and male baldness. Methods: 400 male subjects (25-60 years)at Sobi Specialist Hospital Alagbado, Ilorin, kwara State, Nigeria were recruited into the study(200 for control and 200 for baldness).Blood sample was collected from each subject for blood grouping estimation, following the completion of a questionnaire containing information about baldness and haematological profile. Result: The distribution of phenotypic frequencies of ABO group in the control samples were 26.0%, 28.0%, 4.0% and 42.0% for groups A, B, AB and O, respectively, while 92.0% of the subjects were Rh (D) positive and 8.0% Rh(d) negative. And for the baldness, they were 26.0%, 26.0%, 4.0% and 44% for A, B, AB, and O respectively; while Rh (D) positive were 94.0% and Rh (d) negative were 6.0%. The overall result is statistically insignificant (P>0.05) using Pearson Chi-square. Conclusion: The result reflects an absolute parallel relationship between baldness and ABO/Rhesus blood group systems. Thus, ordering for blood group assessment during routine hair clinic as part of ancillary investigation should be discouraged, except if other interests arise.
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    Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats
    (Published by University of Ilorin, Ilorin, Nigeria, 2012) Ojulari, L. S.; Biliaminu, S. A.; Dangana, E. O.; Abdulazeez, F. I.; Ayinde, T. O.; Adegoke, O. A.
    global health. It contributes to oxidative stress and also induces inflammation and hence severe complications. Several drugs have been introduced so far to salvage this metabolic disease alongside its complications. Objectives: This study was designed to investigate the effects of gliclazide on serum uric acid and C-reactive protein (a biomarker of inflammation) in alloxan-induced diabetic rats. Materials and Methods: Sixteen wistar rats were divided into 4 experimental groups with four rats each; Group A-control (Drug vehicle), Group B-diabetic, Group C- diabetic/gliclazide (10mg/kg twice daily for 28days) and Group D-normal/gliclazide (10mg/kg twice daily for 28 days). At the end of the experimental period (four weeks), animals in all groups were fasted for 12 hours and blood samples were taken by cardiac puncture for determination of serum uric acid and C-reactive protein (CRP) levels. Results: The study shows no significant statistical change in the serum uric acid levels (p>0.05) when the Experimental groups were compared with the controls. On the other hand, there was significant decrease (p<0.05) in CRP levels when values in the controls were compared with diabetic treated and normal treated groups. Conclusion: This finding may suggests that gliclazide possesses cardioprotective property since CRP has been implicated in atherosclerotic changes which is a common complication of diabetes mellitus. This may be through its anti-inflammatory effect by reducing the plasma concentration of IL-6, which is produced predominantly by macrophages and so prevents diabetic complications.
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    Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration
    (Published by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria, 2021) Balogun, M. E.; Umahi, G. O.; Ayinde, T. O.; Oluwasola, A.; Busari, A. O.; Ajibola, K. A.; Yusuf, R. O.; Ojulari, L. S.
    Objective: The ethanolic leaf extract of N. latifolia (EENL) was investigated for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric acid secretion parameters and ulcerated areas were evaluated. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume, total acidity and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal injuries. Conclusion: The study suggests that EENL attenuates gastric acid secretion and ulceration induced by ethanol in Wistar rat. The observed pharmacological activities might be mediated via antisecretory and cytoprotective mechanisms.