Browsing by Author "Akinlade, O.M."

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    38.Prevalence an d predictors of peripheral artery disease among hypertensive patients in a tertiary hospital in north - central Nigeria
    (Kenyan Medical Association., 2023) Yusuf, I.A.; Akinlade, O.M.; Awodun, O.R; Yusuf, W.O.; Ogunmodede, James Ayodele; Kolo, P.M.
    Objective: The objective of the study was to determine the prevalence of peripheral artery disease and its predictors among hypertensive patients attending the University of Ilorin Teaching Hospital. Design: Hospital-based comparative cross-sectional study. Setting: General outpatient clinic and cardiology clinic Participants:150 hypertensive patients and 150 normotensive patients were recruited. Main outcome measures: The participants were physically examined, and their blood samples were taken for analysis. Ankle-brachial index was determined among the participants using a handheld Doppler machine. Data obtained were analyzed using SPSS 20 computer software package. Results: The prevalence of peripheral artery disease among the hypertensive subjects and normotensive patients were 20% and 3.3% respectively. The predictors of peripheral artery disease were age of the patient (OR, 1.04; 95% CI, 1.01 - 1.08), duration of hypertension (OR, 1.08; 95% CI, 1.02 - 1.15), abnormal body mass index (OR, 1.10; 95% CI, 1.02 - 1.20), low-density lipoprotein cholesterol (OR, 3.41; 95% CI, 1.17 - 9.97) and total cholesterol (OR, 5.56; 95% CI, 2.33 - 13.27). Conclusion: Peripheral artery disease is a common complication among hypertensive patients studied. The predictors of peripheral artery disease among Objective: The objective of the study was to determine the prevalence of peripheral artery disease and its predictors among hypertensive patients attending the University of Ilorin Teaching Hospital. Design: Hospital-based comparative cross-sectional study. Setting: General outpatient clinic and cardiology clinic Participants:150 hypertensive patients and 150 normotensive patients were recruited. Main outcome measures: The participants were physically examined, and their blood samples were taken for analysis. Ankle-brachial index was determined among the participants using a handheld Doppler machine. Data obtained were analyzed using SPSS 20 computer software package. Results: The prevalence of peripheral artery disease among the hypertensive subjects and normotensive patients were 20% and 3.3% respectively. The predictors of peripheral artery disease were age of the patient (OR, 1.04; 95% CI, 1.01 - 1.08), duration of hypertension (OR, 1.08; 95% CI, 1.02 - 1.15), abnormal body mass index (OR, 1.10; 95% CI, 1.02 - 1.20), low-density lipoprotein cholesterol (OR, 3.41; 95% CI, 1.17 - 9.97) and total cholesterol (OR, 5.56; 95% CI, 2.33 - 13.27). Conclusion: Peripheral artery disease is a common complication among hypertensive patients studied. The predictors of peripheral artery disease among these patients were age, duration of hypertension, obesity and dyslipidemia
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    Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease
    (Taylor & Francis, 2020) Olabode, O.P.; Akinlade, O.M.; Babatunde, A.S.; Abdulazeez, M.I.; Biliaminu, S.A.; Oyabambi, A.O.; Olatunji, V.A.; Soladoye, A.O.; Olatunji, L.A.
    ABSTRACT We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical, and cardiometabolic parameters among individuals with normal genotype (HbAA; n¼60), SCT (HbAS; n¼60), and SCD (HbSS; n¼60), all in steady state. Using multivariate linear regression analysis, high PP was positively related to TG/HDL-C ratio in SCT (b¼0.307; p¼.014) and PAI-1 (b¼0.499; p¼.001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.