Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
ABSTRACT
We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in
young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical,
and cardiometabolic parameters among individuals with normal genotype (HbAA; n¼60),
SCT (HbAS; n¼60), and SCD (HbSS; n¼60), all in steady state. Using multivariate linear regression
analysis, high PP was positively related to TG/HDL-C ratio in SCT (b¼0.307; p¼.014) and PAI-1
(b¼0.499; p¼.001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C
ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This
study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would
promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.
Description
Keywords
Plasminogen activator inhibitor-1;, pulse pressure;, sickle cell disease;, sickle cell trait, triglyceride/high-density lipoprotein ratio;
Citation
Olabode, O.P., Akinlade, O.M., Babatunde, A.S., Abdulazeez, M.I., Biliaminu, S.A., Oyabambi, A..O, Olatunji, V.A., Soladoye, A..O, & Olatunji, L.A. (2018): Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. Archives of Physiology and Biochemistry, 126(2):166-171.