Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease

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dc.contributor.authorOlabode, O.P.
dc.contributor.authorAkinlade, O.M.
dc.contributor.authorBabatunde, A.S.
dc.contributor.authorAbdulazeez, M.I.
dc.contributor.authorBiliaminu, S.A.
dc.contributor.authorOyabambi, A.O.
dc.contributor.authorOlatunji, V.A.
dc.contributor.authorSoladoye, A.O.
dc.contributor.authorOlatunji, L.A.
dc.date.accessioned2020-05-22T22:47:29Z
dc.date.available2020-05-22T22:47:29Z
dc.date.issued2020
dc.description.abstractABSTRACT We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical, and cardiometabolic parameters among individuals with normal genotype (HbAA; n¼60), SCT (HbAS; n¼60), and SCD (HbSS; n¼60), all in steady state. Using multivariate linear regression analysis, high PP was positively related to TG/HDL-C ratio in SCT (b¼0.307; p¼.014) and PAI-1 (b¼0.499; p¼.001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.en_US
dc.identifier.citationOlabode, O.P., Akinlade, O.M., Babatunde, A.S., Abdulazeez, M.I., Biliaminu, S.A., Oyabambi, A..O, Olatunji, V.A., Soladoye, A..O, & Olatunji, L.A. (2018): Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. Archives of Physiology and Biochemistry, 126(2):166-171.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/3965
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectPlasminogen activator inhibitor-1;en_US
dc.subjectpulse pressure;en_US
dc.subjectsickle cell disease;en_US
dc.subjectsickle cell traiten_US
dc.subjecttriglyceride/high-density lipoprotein ratio;en_US
dc.titleTriglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and diseaseen_US
dc.typeArticleen_US

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