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Browsing by Author "AJADI, A.A."

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Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide- induced anaemia in rats
(DE GRUYTER, 2020-05-15) ATATA, J.A.; AYOOLA, T.O.; AJADI, A.A.; ADAMU, S.; OLATUNJI, A.O.; BIOBAKU, K.T.
Background: The folkloric claim that Cnidoscolus aconiti- folius (Chaya) could ameliorate anaemia requires scientific revalidation in anaemic models. Objective: The aim of this study is to investigate the anti- anaemic effect of Cnidoscolus aconitifolius on cyclophos- phamide-induced anaemia in rats. Methods: The leaves of Cnidoscolus aconitifolius were collected, dried and extracted with ethanol. Twenty five Wistar Albino rats weighing 120–180 kg were used. Anaemia was induced in groups 2, 3, 4 and 5 with a single injection of cyclophosphamide, while group 1 served as a negative control without anemia and was treated with 0.5 mL of normal saline, Group 2 rats were treated with 100 mg/kg body weight of Cnidoscolus aconitifolius. Group 3 rats were treated with 500 mg/kg body weight of Cnido- scolus aconitifolius. Group 4 served as the positive control rats and was treated with 0.5 mL of normal saline. Group 5 which served as the standard control rats and were treated with 5 mg/kg body weight of standard drug Chemiron. The treated lasted for two weeks during which blood samples were collected from each rat for haematological analysis. Results: The result shows that hematological parame- ters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol extract of Cnidoscolus aconitifolius and chemiron respectively. Conclusions: Ethanol leaf extract of Cnidoscolus aconiti- folius at a graded dose of 500 mg/kg body weight had higher ameliorative effect on the haematological parame- ters of cyclophosphamide-induced anemia in rats.
Dexamethasone-induced stress exacerbates shedding, tissue antigen distribution, and pathology of caprine Brucellosis
(TAYLOR & FRANCIS, 2021-02-12) TANKO, POLYCARP; SABRI, M.Y.; EMIKPE, B.O.; ONILUDE, O.M.; AJADI, A.A.
This study investigated dexamethasone-treatment, shedding routes, tissue antigen distribution, and pathology of caprine Brucellosis. Eighteen non-pregnant goats were randomly grouped into A, B, and C. Group A was administered dexametha- sone for 7 days at 2 mg/kg before inoculating 0.5 mL B. melitensis at 107 CFU ocularly while group B was inoculated 0.5 mL B. melitensis only, and C as control negative. Blood samples, ocular, nasal, and vaginal swabs were obtained for evaluation. Three goats were sacrificed from each group at days 21 and 42 post-inoculation (pi) and selected tissues col- lected for PCR, histopathology, and immunohistochemistry. Brucella melitensis was detected in the ocular swabs of group A significantly higher than group B. Shedding was prolonged in group A compared to B. The overall shedding was 22.2% in group A and 9.4% in group B. The uterus of both groups A and B revealed mild inflammation and microgranuloma, extensive necrotic lesions in lymph nodes. Liver showed multi- focal necrosis predominantly in group A. Lesion scoring showed significantly higher scores in A compared to B. Strong immu- nostaining was observed in the liver, lungs, and spleen, predo- minantly at day 21 pi. This study demonstrated dexamethasone prolonged shedding, tissue antigen distribution, and pathology in dexamethasone-treated goats.
Effect of diet modification with iron-on haematological and biochemical parameters of non-anaemic puppies
(College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Niger, 2024-12-14) ATATA, J.A.; OMOTOSHO, G.S.; AJADI, A.A.; ADAM, M.; AKANBI, O.B.; JEGEDE, H.O.; OLATUNJI, A.O.
Dietary iron intake is vital for proper growth and development in puppies. The aim of this study was to examine the effects of diet modification with iron on haematological and biochemical parameters of puppies. A total of ten apparently healthy puppies weighing between 4.3 – 6.5 kg were used for this study. They were assigned to two groups of five dogs each. Group I was iron-supplemented, while group II served as non-iron supplemented control. Puppies in group I were fed diet modified with iron supplementation, while the group II puppies were fed with puppy food without supplementation. Result of this study revealed significant changes in haematological and biochemical parameters in the iron-supplemented compared to the control. Haemoglobin levels, erythrocyte counts, and the mean corpuscular volume showed significant increases (p0.05). Serum iron was elevated significantly (p0.05) in the iron-supplemented compared to the control group. However, the lipid profile, kidney function markers, oxidative stress biomarkers as well as the activities of the liver enzymes were comparable between the two groups (p>0.05). The findings of this research suggest that iron modified diets improved haematological parameters and iron status in puppies.
Evaluation of Growth, Haematological, Biochemical and Oxidative Stress Parameters of Clarias gariepinus Fed with Alstonia boonei and Mitracarpus scaber
(Central Fisheries Research Institute (SUMAE) Trabzon, Turkey, 2022-03-31) AJADI, A.A.; JIBRIL, A.J.; EMIKPE, B.O.
Synthetic agents as growth promoters in aquaculture has become unpopular, hence, the need for better alternatives. This study was conducted to investigate the effects of dietary plants on growth performance, haematological, biochemical and oxidative stress parameters in African catfish. Fish were fed on basal diets for 84 days, the control and six other experimental diets containing different levels of Alstonia boonei (0.5%,1.0% and 1.5%) and Mitracarpus scaber (0.5%,1.0% and 1.5%) of the basal diets. Fish were weighed bimonthly, blood samples were collected and analyzed. At the end of the experiment, the final weight (FW), weight gain (WG), Average Daily Growth Rate (ADGR) and Specific Growth Rate (SGR) of fish fed with A. boonei and M. scaber were significantly higher than that of control (P<0.05). The values of RBC and haemoglobin of the M. scaber (0.5%) group were significantly higher than the other groups including the control. The values of Heterophil-Lymphocyte Ratio (HLR) and Platelet- Lymphocyte Ratio (PLR) in the control group were significantly higher than those of the treatment groups. Biochemical parameters and oxidative stress markers did not show any significant difference between the treatment groups and the control (P>0.05). The findings clearly indicated that the plants enhanced growth performance in fish with little or no deleterious effects.
Gastric impaction in a 7-month-old Rottweiler: a postmortem examination
(College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria, 2023-11) ADAM, M.; ADEYEYE, T.E.; AKANBI, O.B.; AJADI, A.A.; ATATA, J.A.; ABUBAKAR, M.S.; SHOYINKA, S.V.O.
A dead seven-month-old female Rottweiler dog was presented to the necropsy unit of the University of Ilorin Veterinary Teaching hospital for post-mortem examination. The owner complained of vomiting, salivating, and restlessness prior to the death of the dog. The stomach was filled with black polythene materials at necropsy, weighing 3 Kg. The gastric mucosa was hyperaemic with the right lobes of the lungs severely congested. The heart was globous with prominent coronary vessels. The liver showed areas of diffused necrosis with a slightly enlarged left kidney. Based on the above findings, it was diagnosed as a case of gastric obstruction from nylon. The cause and pathogenesis of gastric impaction are discussed
Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019
(THE LANCET, 2023-09-08) AJADI, A.A.
Background The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. Findings In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. Interpretation The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively. Funding The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (2022QN38).
Haemato-biochemical studies of dogs with haemorrhage-induced dehydration
(Springer Nature, 2018-08-15) ATATA, A.A.; ESIEVO, K.A.AN.; ADAMU, S.; ABDULSALAM, H.; AVAZI, D.O.; AJADI, A.A.
Factors that contribute to water loss in tropical animals are complex and constantly changing. To evaluate the haemato- biochemical parameters of dogs with haemorrhage-induced dehydration. A total of 12 dogs were used; haemorrhage was induced by daily removal of 10 ml of blood over a period of 28 days and analysed at the Department of Veterinary Pathology, Ahmadu Bello University (A.B.U.), Zaria, Nigeria. Dehydration was clinically assessed. Age, sex, body weight and generalised body condition of the animals were determined. Whole blood was collected for determination of haematological parameters. Serum was prepared from whole blood to determine the concentrations of urea, creatinine, total protein, albumin, glucose, sodium, calcium, chloride, phosphorus, potassium, bicarbonate, blood urea nitrogen (BUN)/creatinine ratio and anion gap (AG) as well as serum activities of liver enzymes. Reductions in body weight (1.67 kg, 2.17 kg and 3.17 kg) due to degrees of dehydration were observed on days 14, 21 and 28. Significantly higher values of packed cell volume and haemoglobin concentration (P < 0.01) due to dehydration was observed between days 0 and 14, also between days 0 and 28. Higher concentrations of urea, creatinine (P < 0.01), BUN/creatinine, total protein, albumin and urine specific gravity (P < 0.05) were observed between day 0 and days 14, 21 and 28. This study is the first to report the haemato-biochemical changes of Nigerian local dogs with haemorrhage-induced dehydration. The study did not investigate the role of type of diet on dehydration, and it is recommended that future studies should be carried out to elucidate this.
Haematological Changes Associated with Porcine Haemoparasitic Infections in Ibadan, Oyo State, Nigeria
(2018-09-15) OLAOSEBIKAN, O.O.; ALAKA, O.O.; AJADI, A.A.
The study was carried out between January and July 2016. Blood samples were obtained from 153 pigs by venipuncture and jugular severance at slaughter. The blood samples were examined for all known hemoparasites detectable by light microscopic examination. Haematimetric indices, complete blood cell count and leukocyte differentials were determined. The level of parasitaemia and changes in blood indices were subjected to statistical analysis across seasons. Trypanosoma brucei and Eperythrozoon suis were the only hemoparasites detected in the blood of pigs during the period of sampling. The prevalence of haemoparasitic infections in sampled pigs was 5.23%. T. brucei contributed 3.9% while E. suis contributed 1.31% to the prevalence. Anaemia (PCV<32) was a consistent and significant finding in all parasitemic samples. Eperythrozoon suis caused more severe anaemia (20±9.89) when compared with Trypanosoma brucei (27±3.03). The anaemia caused by E. suis was mostly microcytic normochromic while T. brucei mostly caused normocytic normochromic anaemia. Mild leucopenia was observed in eperythrozoonosis while a moderate lymphocytosis was observed in T. brucei infections. It was observed that in spite of intense chemoprophylaxis and other control measures employed, we still have persistent infections with Eperythrozoon sp and Trypanosomes in our pig population. Further studies should be carried out to detect the possibility of drug resistance by some of these circulating hemoparasites in the pig industry. Attempts should also be made to control the vectors of these parasites which are usually abundant during the rainy season and may be responsible for the higher prevalence recorded during this period
Hematological prediction study of peritonitis following laparotomy in goats
(THE JAPANESE SOCIETY OF VETERINARY SCIENCE, 2020-03-24) ALIMI, O.A.; ABDULWAHAB, W.F.; AMID, S.A.; ABDULKADIR, S.Z.; LAWAL, F.M.; ALIYU, A.; ADEDIRAN, S.O.; AJADI, A.A.; BOLAJI, M.; UTHMAN, H.O.; ADEYANJU, J.B.
Surgical trauma to the abdominal wall and peritoneum during celiotomy is expected to cause postoperative inflammation. However, complications after abdominal surgery are hardly detected in the early stage. Hematological analysis of blood has been considered beneficial in disease diagnosis and prognosis. This study aimed to evaluate the hematological parameters predicting peritonitis in goats and to determine the post-surgery day that hematology is significant. Six apparently healthy West African Dwarf goats were included in this study. After 2 weeks of acclimatization, blood samples were obtained daily for 3 days for hematological analyses, which served as the baseline data. The right flanks of the animals were aseptically prepared routinely for exploratory laparotomy. Restraint and anesthesia were achieved using xylazine and lignocaine using an inverted “L” block technique. Laparotomy was performed, and the incision was left for 20 min and then closed routinely. Blood samples were collected for hemogram 24 hr postoperatively and daily for 7 days. Based on the post-surgery hematology results, relative neutrophil (P=0.015) and lymphocyte (P=0.006) counts significantly increased and decreased on day 5 respectively. Significant differences were also observed for red blood cell count, hemoglobin concentration, and packed cell volume on days 5, 6, and 7 respectively. It could therefore be concluded that the diagnostic result for hematology post-laparotomy can be obtained on the fifth and sixth day
Invitro Antimicrobial Activities of Mitracarpus scaber Against Some Common Bacteria of Aquatic Origin
(FACULTY OF VETERINARY MEDICINE, UNIVERSITAS AIRLANGGA, INDONESIA, 2021-09-08) AJADI, A.A.; EMIKPE, B.O.; AHMED, A.O.
Some plants have been reported to be of medicinal values and reserve some antimicrobial properties. One of such plants is Mitracarpus scaber and its effect on bacterial growth is evaluated. The study aimed at evaluating the phytochemical analyses and antimicrobial potentials of Mitracarpus scaber against aquatic bacteria. Leaves of Mitracarpus scaber and phytochemical analysis and antimicrobial investigation of ethanolic and aqueous extracts of the leaves were carried out against bacteria isolated from diseased Catfish from various farms. The phytoconstituents detected include saponins, tannins, flavonoids, tarpenoids, steroids, anthraquinones and alkaloids in both aqueous and ethanolic extracts. The ethanolic extract had zones of inhibition similar to that of standard antibiotics (enrofloxacin) across all tested microbes. The lowest minimum inhibitory concentration of ethanolic extract of M. scaber was against Bacillus sp with 10mg/ml while the highest was 85mg/ml against Staphylococcus species. The results of the assays showed promising evidences that M. scaber is a potential antibacterial agent against aquatic microbes. However, further studies are recommended to fractionate its constituents and determine the in vitro and in vivo anti-microbial activities and the exact mechanism of action of the constituents.
Protective Evaluation of Feed Fortified with Alstonia Boonei and Mitracarpus Scaber in African Catfish Exposed to Aeromonas Hydrophila: Clinicopathology and Immunohistochemistry
(Central Fisheries Research Institute (SUMAE) Trabzon, Turkey, 2022-11-25) AJADI, A.A.; JARIKRE, T.A.; JIBRIL, A.J.; EMIKPE, B.O.
The present study was carried out to determine the protective effects of two dietary plants and the associated pathology in African catfish exposed to A. hydrophila. Four hundred and twenty fish with average weight of 20.53±0.15 g were distributed equally (in triplicates) into seven experimental groups (six treatment groups and a control group) with 20 juvenile African catfish in each aquarium. Fish were fed for 84 days with control and six other experimental diets containing different percentages of Alstonia boonei (0.5%,1.0% and 1.5%) and Mitracarpus scaber (0.5%,1.0% and 1.5%) of the basal diets. At the end of 12th week, the fish were challenged with A. hydrophila and clinical signs and mortality rate were observed for fourteen days, post challenge. Blood and tissue samples were collected for analysis. All the groups fed with plant supplemented feed had 100% survival rate except A. boonei (0.5%) with 85% and control had 70% survival rate. The dietary plants also improved the haematological parameters and reduced the histopathological lesions associated with A. hydrophila exposure, compared to the control. These findings have demonstrated the protective potentials of A. boonei and M. scaber inculcated in feed against A. hydrophila infection in African catfish.
Retrospective Study of Canine Pathologies Causing Mortalities in Ilorin Kwara State, Nigeria
(Egyptian Society for Animal Management (ESAM), 2024-04-01) ADAM, M.; AJADI, A.A.; ATATA, J.A.; AKANBI, O.B.; SHOYINKA, S.V.O.; ABUBAKAR, M.S.; OLANIYI, M.O.
Canine pathologies refer to the various diseases, disorders, and abnormalities that can affect a dog’s different body systems and cause mortality. The primary aim of this study was to investigate the common pathologies that are associated with the mortality of dogs in Ilorin, Kwara State. A retrospective review of post-mortem records from 7 years was undertaken at a necropsy unit of the Department of Veterinary Pathology, University of Ilorin. Data collected included age, sex, breed, disease pathogens, and year. A total of 150 dog carcasses were presented for necropsy during the period between January 2016 and December 2022. In this study, the cases used were confirmed based on PCR results in some cases, bacterial culture and isolation, parasite identification, gross lesions, and histopathological findings in other cases. Descriptive statistics were employed to evaluate the effect of disease pathogens on age, sex, and breed distribution patterns associated with the mortality of dogs. The prevalence of viral infection among other diseases was statistically significant (34.00%; OR = 0.53; P<0.01). The percentage prevalence of each disease showed that bacterial infections were evident, with Staphylococcosis being the most prevalent at 49.01%, followed by Salmonellosis at 7.84%, Leptospirosis at 23.53%, and Brucellosis at 19.6%. Parasitic infections were also notable, encompassing canine babesiosis (34.80%), acariosis (39.10%), and canine ehrlichiosis (26.08%). Toxicosis cases were largely dominated by diclovous poisoning, constituting 88.88% of instances, while medication toxicity was observed in 11.11% of cases. Neoplastic conditions were represented by hepatic lymphoma, with a prevalence of 1%, while nutritional deficiencies included hepatic lipidosis, noted in 1% of cases. Traumatic injuries were common, with bone fracture having the highest prevalence at 66.67% and muscle laceration observed in 33.33% of cases. Intestinal obstruction cases, specifically gastric impaction, were noted in 1% of cases. Viral infections comprised parvovirus infection with the highest prevalence at 81%, and canine distemper was observed in 18.92% of cases. In conclusion, this study has exposed the leading causes of mortalities among the dog population, which include parvovirus enteritis, staphylococcosis, and acariosis infections. The emphasis should be on preventive measures to curtail disease transmission and associated financial loss.
Surveillance for avian influenza virus in captive wild birds and indigenous chickens in Nigeria
(SPRINGER NATURE, 2020-03-13) DAODU, O.B.; JEGEDE, H.O.; AIYEDUN, J.O.; OLUDAIRO, O.O.; OLORUNSHOLA, I.D.; AJADI, A.A.; AMBALI, S.F.
Several reports of avian influenza virus (AIV) have been made on commercial chickens and wild birds in sub-Saharan Africa, but there is paucity of information of AIV among captive wild birds and indigenous chickens. Blood samples were obtained randomly from captive wild birds and chickens. AIV nucleoprotein antibody detection involved the use of enzyme immunoassay (ELISA) and subsequent subtyping with H5 and H7 AIV antigens (haemagglutination inhibition). Four hundred birds belonging to nine families and 14 species were sampled, and overall prevalence of 23% (92/400) was obtained (captive wild birds (10.4%, 5/48), indigenous birds (47.3%, 87/184) and exotic commercial birds (0.0%, 0/168)). Twelve ELISA-positive birds (13.04%) were positive to H7 antigen. Univariate analysis indicated statistical significance of AIV prevalence in captive wild birds (p < 0.0001) and exotic birds (p < 0.0001) using indigenous chickens as reference. This study gave an evidence of exposure of captive wild birds and indigenous chickens to AIV in Nigeria. Scavenging activities common among indigenously raised chickens, unrestricted movement of nonflying wild birds within the captive complex and free access by migrating wild birds to captive wild birds and local chickens were likely factors observed to promote AIV transmission. Continuous surveillance can further highlight the roles played by these birds in the epidemiology of AIV.
The effect of anaesthetic agents on the haematological parameters of adult African Catfish (Heterobranchus bidorsalis)
(Faculty of Veterinary Medicine, University of Ilorin, 2024-03-14) AJADI, A.A.; AGBOOLA, W.O.; DAUDA, A.B.; ADAM, M.; ATATA, J.A.; AKANBI, O.B.; BADAMASI, A.O.; BOLAJI, M.; EMIKPE, B.O.
Introduction: The haematological parameters of giant African catfish exposed to different anaesthetic agents, such as lidocaine, clove oil, and ice, and the control with no exposure were examined. Methods: Ten fish each from the control and treatment groups had their blood drawn and the samples were examined immediately for haematological parameters. One-way analysis of variance was used to compare each of the parameters among the treatment groups and the control. Results: The highest red blood cell (RBC), Haemoglobin, and parked cell volume (PCV) were observed in the control and they were different significantly (P<0.05) from the fish exposed to clove oil. Mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin (MCHC) were significantly higher (P<0.05) in the control than in all the treatment groups. The highest heterophil was observed in the fish exposed to ice and it was different significantly (P<0.05) from the control treatment. Platelet was significantly higher in the control and lidocaine treatments than in clove oil. The least heterophil-lymphocyte ratio (HLR) was also observed in the control and it was different significantly (P<0.05) from fish ice treatment. The PLR of lidocaine and ice treatments were higher significantly (P<0.05) than the control, while that of clove oil was much lower than the control. Significance: The findings from the research showed that all the anaesthetics experimented with had considerable negative impacts on the fish's haematological parameters, with clove oil tending to be the worst. Hence, extra care is required in using any of these treatments on fish, and the recommended dosages must be followed.

Browsing by Author "AJADI, A.A."

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