Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide- induced anaemia in rats
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Date
2020-05-15
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Journal ISSN
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DE GRUYTER
Abstract
Background: The folkloric claim that Cnidoscolus aconiti-
folius (Chaya) could ameliorate anaemia requires scientific
revalidation in anaemic models.
Objective: The aim of this study is to investigate the anti-
anaemic effect of Cnidoscolus aconitifolius on cyclophos-
phamide-induced anaemia in rats.
Methods: The leaves of Cnidoscolus aconitifolius were
collected, dried and extracted with ethanol. Twenty five
Wistar Albino rats weighing 120–180 kg were used.
Anaemia was induced in groups 2, 3, 4 and 5 with a single
injection of cyclophosphamide, while group 1 served as a
negative control without anemia and was treated with
0.5 mL of normal saline, Group 2 rats were treated with
100 mg/kg body weight of Cnidoscolus aconitifolius. Group
3 rats were treated with 500 mg/kg body weight of Cnido-
scolus aconitifolius. Group 4 served as the positive control
rats and was treated with 0.5 mL of normal saline. Group 5
which served as the standard control rats and were treated
with 5 mg/kg body weight of standard drug Chemiron. The
treated lasted for two weeks during which blood samples
were collected from each rat for haematological analysis.
Results: The result shows that hematological parame-
ters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol
extract of Cnidoscolus aconitifolius and chemiron respectively.
Conclusions: Ethanol leaf extract of Cnidoscolus aconiti-
folius at a graded dose of 500 mg/kg body weight had
higher ameliorative effect on the haematological parame-
ters of cyclophosphamide-induced anemia in rats.
Description
Keywords
anaemia, Cnidoscolus aconitifolius, cyclophos- phamide, haematinic, rat.