Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide- induced anaemia in rats

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dc.contributor.authorATATA, J.A.
dc.contributor.authorAYOOLA, T.O.
dc.contributor.authorAJADI, A.A.
dc.contributor.authorADAMU, S.
dc.contributor.authorOLATUNJI, A.O.
dc.contributor.authorBIOBAKU, K.T.
dc.date.accessioned2024-04-22T10:24:12Z
dc.date.available2024-04-22T10:24:12Z
dc.date.issued2020-05-15
dc.description.abstractBackground: The folkloric claim that Cnidoscolus aconiti- folius (Chaya) could ameliorate anaemia requires scientific revalidation in anaemic models. Objective: The aim of this study is to investigate the anti- anaemic effect of Cnidoscolus aconitifolius on cyclophos- phamide-induced anaemia in rats. Methods: The leaves of Cnidoscolus aconitifolius were collected, dried and extracted with ethanol. Twenty five Wistar Albino rats weighing 120–180 kg were used. Anaemia was induced in groups 2, 3, 4 and 5 with a single injection of cyclophosphamide, while group 1 served as a negative control without anemia and was treated with 0.5 mL of normal saline, Group 2 rats were treated with 100 mg/kg body weight of Cnidoscolus aconitifolius. Group 3 rats were treated with 500 mg/kg body weight of Cnido- scolus aconitifolius. Group 4 served as the positive control rats and was treated with 0.5 mL of normal saline. Group 5 which served as the standard control rats and were treated with 5 mg/kg body weight of standard drug Chemiron. The treated lasted for two weeks during which blood samples were collected from each rat for haematological analysis. Results: The result shows that hematological parame- ters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol extract of Cnidoscolus aconitifolius and chemiron respectively. Conclusions: Ethanol leaf extract of Cnidoscolus aconiti- folius at a graded dose of 500 mg/kg body weight had higher ameliorative effect on the haematological parame- ters of cyclophosphamide-induced anemia in rats.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/12427
dc.language.isoen
dc.publisherDE GRUYTER
dc.subjectanaemia
dc.subjectCnidoscolus aconitifolius
dc.subjectcyclophos- phamide
dc.subjecthaematinic
dc.subjectrat.
dc.titleAnti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide- induced anaemia in rats
dc.typeArticle

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