Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies
dc.contributor.author | Issa, A | |
dc.contributor.author | Abdulkadir, Mohammed Baba | |
dc.contributor.author | Ibraheem, Rasheedat Mobolaji | |
dc.contributor.author | Ibrahim, O.R | |
dc.contributor.author | Bello, S.O | |
dc.contributor.author | Suberu, H.D. | |
dc.contributor.author | Sanusi, I | |
dc.date.accessioned | 2023-01-09T13:04:02Z | |
dc.date.available | 2023-01-09T13:04:02Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background: A proper evaluation of cardiovascular status, with a view to ensuring early diagnosis of cardiac dysfunction and prompt intervention where necessary, is a recognized approach in the management of asphyxiated neonates. Hence, we determined the levels of a cardiac biomarker (troponin I), its relationship with disease severity, and mortality in asphyxiated neonates with hypoxic–ischemic encephalopathy (HIE). Methods: This was a descriptive study that involved 85 asphyxiated, term appropriate‑for‑gestational age newborn babies with HIE (subjects) and 85 healthy controls within the first 72 h of life. Asphyxiated neonates were classified into HIE stages using Sarnat and Sarnat staging. Blood samples were collected between 24 and 72 h of life to determine the level of troponin I using enzyme‑linked immunosorbent assay. The asphyxiated babies were followed up till discharge or death. Results: The median interquartile range level of troponin I in the subjects was higher compared with the controls, 1.26 (0.97–3.16) ng/ml versus 0.79 (0.79–1.42) ng/ml, P < 0. 001. The levels of troponin I in HIE I, HIE II, and HIE III were 1.26 (1.00–2.37) ng/ml, 1.11 (0.86– 2.96) ng/ml, and 3.58 (1.34–5.58) ng/ml, respectively. Nonsurvivors had a higher cardiac troponin I (4.00 [2.30–6.34] ng/ml) compared with survivors (1.21 [0.95– 2.37] ng/ml), P = 0.015. Conclusion: Cardiac troponin I was significantly higher in asphyxiated subjects compared with healthy controls. Elevated troponin I was associated with higher mortality. Troponin I levels in the first 72 h can help as a prognostic indicator of HIE in term babies | en_US |
dc.identifier.citation | Issa, A., Abdulkadir, M. B., Ibraheem, R. M., Ibrahim, O. R., Bello, S. O., Suberu, H., & Sanusi, I. (2021). Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies. Journal of Clinical Neonatology, 10(3), 187-191 | en_US |
dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/8283 | |
dc.publisher | Saudi Neonatology Society | en_US |
dc.subject | Hypoxic–ischemic encephalopathy, mortality, newborn babies, troponin I | en_US |
dc.title | Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies | en_US |
dc.type | Article | en_US |
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