Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies


Background: A proper evaluation of cardiovascular status, with a view to ensuring early diagnosis of cardiac dysfunction and prompt intervention where necessary, is a recognized approach in the management of asphyxiated neonates. Hence, we determined the levels of a cardiac biomarker (troponin I), its relationship with disease severity, and mortality in asphyxiated neonates with hypoxic–ischemic encephalopathy (HIE). Methods: This was a descriptive study that involved 85 asphyxiated, term appropriate‑for‑gestational age newborn babies with HIE (subjects) and 85 healthy controls within the first 72 h of life. Asphyxiated neonates were classified into HIE stages using Sarnat and Sarnat staging. Blood samples were collected between 24 and 72 h of life to determine the level of troponin I using enzyme‑linked immunosorbent assay. The asphyxiated babies were followed up till discharge or death. Results: The median interquartile range level of troponin I in the subjects was higher compared with the controls, 1.26 (0.97–3.16) ng/ml versus 0.79 (0.79–1.42) ng/ml, P < 0. 001. The levels of troponin I in HIE I, HIE II, and HIE III were 1.26 (1.00–2.37) ng/ml, 1.11 (0.86– 2.96) ng/ml, and 3.58 (1.34–5.58) ng/ml, respectively. Nonsurvivors had a higher cardiac troponin I (4.00 [2.30–6.34] ng/ml) compared with survivors (1.21 [0.95– 2.37] ng/ml), P = 0.015. Conclusion: Cardiac troponin I was significantly higher in asphyxiated subjects compared with healthy controls. Elevated troponin I was associated with higher mortality. Troponin I levels in the first 72 h can help as a prognostic indicator of HIE in term babies



Hypoxic–ischemic encephalopathy, mortality, newborn babies, troponin I


Issa, A., Abdulkadir, M. B., Ibraheem, R. M., Ibrahim, O. R., Bello, S. O., Suberu, H., & Sanusi, I. (2021). Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies. Journal of Clinical Neonatology, 10(3), 187-191