Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies
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Date
2021
Authors
Issa, A
Abdulkadir, Mohammed Baba
Ibraheem, Rasheedat Mobolaji
Ibrahim, O.R
Bello, S.O
Suberu, H.D.
Sanusi, I
Journal Title
Journal ISSN
Volume Title
Publisher
Saudi Neonatology Society
Abstract
Background: A proper evaluation of cardiovascular status, with a view to
ensuring early diagnosis of cardiac dysfunction and prompt intervention
where necessary, is a recognized approach in the management of asphyxiated
neonates. Hence, we determined the levels of a cardiac biomarker (troponin I),
its relationship with disease severity, and mortality in asphyxiated neonates
with hypoxic–ischemic encephalopathy (HIE). Methods: This was a descriptive
study that involved 85 asphyxiated, term appropriate‑for‑gestational age newborn
babies with HIE (subjects) and 85 healthy controls within the first 72 h of life.
Asphyxiated neonates were classified into HIE stages using Sarnat and Sarnat
staging. Blood samples were collected between 24 and 72 h of life to determine
the level of troponin I using enzyme‑linked immunosorbent assay. The asphyxiated
babies were followed up till discharge or death. Results: The median interquartile
range level of troponin I in the subjects was higher compared with the controls,
1.26 (0.97–3.16) ng/ml versus 0.79 (0.79–1.42) ng/ml, P < 0. 001. The levels of
troponin I in HIE I, HIE II, and HIE III were 1.26 (1.00–2.37) ng/ml, 1.11 (0.86–
2.96) ng/ml, and 3.58 (1.34–5.58) ng/ml, respectively. Nonsurvivors had a higher
cardiac troponin I (4.00 [2.30–6.34] ng/ml) compared with survivors (1.21 [0.95–
2.37] ng/ml), P = 0.015. Conclusion: Cardiac troponin I was significantly higher
in asphyxiated subjects compared with healthy controls. Elevated troponin I was
associated with higher mortality. Troponin I levels in the first 72 h can help as a
prognostic indicator of HIE in term babies
Description
Keywords
Hypoxic–ischemic encephalopathy, mortality, newborn babies, troponin I
Citation
Issa, A., Abdulkadir, M. B., Ibraheem, R. M., Ibrahim, O. R., Bello, S. O., Suberu, H., & Sanusi, I. (2021). Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies. Journal of Clinical Neonatology, 10(3), 187-191