Role of high-density lipoprotein in the ameliorative activity of Bryophyllum pinnatum in male Wistar rats fed a high fat diet.
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Date
2020
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Faculty of Basic Medical Sciences, Lagos State, University College of Medicine, Lagos, Nigeria
Abstract
Atherosclerosis, a condition connected with fat-rich diet is a leading cause of death worldwide. It has been
strongly associated with dysmetabolic, dyslipidemic and inflammatory conditions with sparingly effective
available therapeutic measures. High-density lipoprotein (HDL-C), the agreeably beneficial chylomicron,
has been linked to improved glycemic control, a finding being growingly investigated.
Bryophyllumpinnatum (BP) aqueous leaf extract or its steroidal derivative is well known for antidiabetic
and/or anti-inflammatory potential. This study therefore investigated the effect of BPon circulating lipids,
inflammatory response markers, and glycemic control in male Wistar rats fed a high-fat diet. Twenty-four
male Wistar rats (120-130 g) were randomly selected into four groups (n=6) and fed with rat chow, high-fat
diet (HFD), HFD + BP (250 mg/kg), and rat chow + BP (250 mg/kg)for six weeks after two weeks of
acclimatization. High-fat-fed rats showed reduced HDL-C, increased fasting glycemia, plasma triglycerides
(TG), low-density-lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), and uric acid (UA). The total
cholesterol was not altered in HFD group. The BP leaf aqueous extract however augmented HDL-C with
accompanying improved fasting glycemia and attenuated plasma TG, TC, LDL-C, CRP, and UAin high fat fed rats. The extract was demonstrated to confer protection against lethal accumulation of atherogenic lipids
and cause the augmentation of HDL-C with a plausible resultant improvement of glycemic control and
amelioration of inflammatory response in high-fat diet-fed animals.
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Keywords
Bryophyllumpinnatum, Male Wistar rats, High Fat Diet (HFD), High Density Lipoprotein, Inflammation, Glycemic control
Citation
A.O. Oyabambi et. al