Role of high-density lipoprotein in the ameliorative activity of Bryophyllum pinnatum in male Wistar rats fed a high fat diet.

Simple item page
dc.contributor.authorOyabambi, A.O
dc.contributor.authorSaliu, S.B
dc.contributor.authorErdoo, A
dc.contributor.authorAkinsanya, Z.O
dc.date.accessioned2021-06-09T09:16:43Z
dc.date.available2021-06-09T09:16:43Z
dc.date.issued2020
dc.description.abstractAtherosclerosis, a condition connected with fat-rich diet is a leading cause of death worldwide. It has been strongly associated with dysmetabolic, dyslipidemic and inflammatory conditions with sparingly effective available therapeutic measures. High-density lipoprotein (HDL-C), the agreeably beneficial chylomicron, has been linked to improved glycemic control, a finding being growingly investigated. Bryophyllumpinnatum (BP) aqueous leaf extract or its steroidal derivative is well known for antidiabetic and/or anti-inflammatory potential. This study therefore investigated the effect of BPon circulating lipids, inflammatory response markers, and glycemic control in male Wistar rats fed a high-fat diet. Twenty-four male Wistar rats (120-130 g) were randomly selected into four groups (n=6) and fed with rat chow, high-fat diet (HFD), HFD  +  BP (250 mg/kg), and rat chow + BP (250 mg/kg)for six weeks after two weeks of acclimatization. High-fat-fed rats showed reduced HDL-C, increased fasting glycemia, plasma triglycerides (TG), low-density-lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), and uric acid (UA). The total cholesterol was not altered in HFD group. The BP leaf aqueous extract however augmented HDL-C with accompanying improved fasting glycemia and attenuated plasma TG, TC, LDL-C, CRP, and UAin high fat fed rats. The extract was demonstrated to confer protection against lethal accumulation of atherogenic lipids and cause the augmentation of HDL-C with a plausible resultant improvement of glycemic control and amelioration of inflammatory response in high-fat diet-fed animals.en_US
dc.description.sponsorshipNILen_US
dc.identifier.citationA.O. Oyabambi et. alen_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/6061
dc.language.isoenen_US
dc.publisherFaculty of Basic Medical Sciences, Lagos State, University College of Medicine, Lagos, Nigeriaen_US
dc.relation.ispartofseries4(1):10-15;
dc.subjectBryophyllumpinnatumen_US
dc.subjectMale Wistar ratsen_US
dc.subjectHigh Fat Diet (HFD)en_US
dc.subjectHigh Density Lipoproteinen_US
dc.subjectInflammationen_US
dc.subjectGlycemic controlen_US
dc.titleRole of high-density lipoprotein in the ameliorative activity of Bryophyllum pinnatum in male Wistar rats fed a high fat diet.en_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
OyabambiAO.pdf
Size:
2.76 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections