Sodium acetate ameliorated systemic and renal oxidative stress in high-fructose insulin-resistant pregnant Wistar rats

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dc.contributor.authorOyabambi, Adewumi Oluwafemi
dc.contributor.authorMichael, Olugbenga Samuel
dc.contributor.authorAreola, Emmanuel Damilare
dc.contributor.authorSaliu, Salam Babatunde
dc.contributor.authorOlatunji, Lawrence Aderemi
dc.date.accessioned2025-05-12T09:01:29Z
dc.date.available2025-05-12T09:01:29Z
dc.date.issued2021-02-27
dc.description.abstractPregnancy is an insulin-resistant condition, especially at near term predisposing maternal kidneys to hyperinsulinemia-induced oxidative stress. The impact of fructose on renal metabolic dysregulation and oxidative stress in pregnancy requires elucidation. Short-chain fatty acids (SCFAs) are known for protective roles in oxidative stress conditions. Therefore, the study aimed at investigating fructose-induced glucose dysregulation and renal oxidative stress in pregnant and non-pregnant rats and the possible preventive role of SCFA, acetate. Thirty female Wistar rats were grouped (n = 5/group). Three groups were made pregnant (P); the other three remained non-pregnant (NP). Both pregnant and non-pregnant rats received drinking water (control), 10% fructose (w/v) (NP+F or P+F), and 10% (w/v) fructose plus sodium acetate (200 mg/kg) (NP+F+A or P+F+A) for 3 weeks. Renal and plasma glutathione antioxidant index (GSH/GSSG), G6PDH, and adenosine were significantly lower in NP+F and P+ F groups compared with control while renal and plasma adenosine deaminase (ADA), xanthine oxidase (XO), uric acid (UA), lactate dehydrogenase (LDH), and malonaldehyde (MDA) were significantly elevated in NP+F and P+F groups compared with controls. HOMA-IR showed marked impairment in both NP+F and P+F groups. The P+F group revealed greater suppression in plasma and renal G6PDH-dependent antioxidant index, adenosine, and aggravation of LDH, MDA compared with the NP+F group (p < 0.05). Sodium acetate reduces plasma and renal surrogate oxidative stress markers, improved G6PD-dependent antioxidant index, and HOMA-IR in NP+F and P+F groups. Pregnancy exacerbates fructose-induced insulin resistance and renal oxidative stress whereas acetate ameliorated fructose-induced redox and glucose dysregulation in pregnant and non pregnant rats.
dc.description.sponsorshipThere was no funding for this research work
dc.identifier.citationOyabambi, A. O., Michael, O. S., Areola, E. D., Saliu, S. B., & Olatunji, L. A. (2021). Sodium acetate ameliorated systemic and renal oxidative stress in high-fructose insulin-resistant pregnant Wistar rats. Naunyn-Schmiedeberg's archives of pharmacology, 394(7), 1425–1435. https://doi.org/10.1007/s00210-021-02058-6
dc.identifier.uri10.1007/s00210-021-02058-6
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16674
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofseries394(7); 1425–1435
dc.subjectSodium acetate
dc.subjectGlucose dysregulation
dc.subjectPregnancy
dc.subjectOxidative stress
dc.subjectFructose
dc.titleSodium acetate ameliorated systemic and renal oxidative stress in high-fructose insulin-resistant pregnant Wistar rats
dc.typeArticle

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