Phoenix dactylifera and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats

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dc.contributor.authorAdana, M. Y.
dc.contributor.authorIbiyeye, R.
dc.contributor.authorSulaimon, F.
dc.contributor.authorImam, A.
dc.contributor.authorOkesina, A.
dc.contributor.authorAjao, M.
dc.date.accessioned2025-05-16T15:38:43Z
dc.date.available2025-05-16T15:38:43Z
dc.date.issued2023
dc.description.abstractMonosodium glutamate (MSG) has been known to cause neurodegeneration, due to its ability to trigger excitotoxicity, and the hippocampus is one of the most affected regions. Therefore, Phoenix dactylifera (P. dactyliferaa ) and polyphenols were employed in this study to mitigate on the deleterious effect of monosodium glutamate on the dentate gyrus of Wistar rats. Forty-eight male Wistar rats weighing between 120-150g was used for the study. The Wistar rats were grouped into eight, (n=6). Groups 1-8 received 1.6mL/kg normal saline, 4000mg\kg monosodium glutamate for 7-days, 4000mg\kg monosodium glutamate for 7-days and 100mg\kg caffeic-acid for 14-days concurrently, 4000mg\kg monosodium glutamate for 7-days and 100mg\kg P. dactyliferaa for 14-days concurrently, 4000mg\kg monosodium glutamate for 7-days and 100mg\kg luteolin for 14-days concurrently, 100mg\kg. caffeic-acid for 14-days followed by 4000mg\kg monosodium glutamate for 7-days, 100mg\kg P. dactyliferaa for 14-days followed by 4000mg\kg monosodium glutamate for 7-days and 100mg\kg luteolin for 14-days followed by 4000mg\kg monosodium glutamate for 7-days respectively. After the treatments, the rats underwent behavioural test (Y-maze test), and subsequently, the brain tissues were processed for histological (Hematoxylin & Eosin stain) and biochemical (superoxide dismustase, glutathione peroxidase and malondialdehyde) analyses. The activities of P. dactyliferaa and polyphenols ameliorated the deleterious effect of monosodium glutamate, through increased spontaneous alternation of the experimental animals, dominant matured granule cells of the dentate gyrus and modulated the activities of superoxide dismutase, glutathione peroxidase and malondialdehyde in the male Wistar rats. Therefore, this study revealed that P. dactyliferaa and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats.
dc.identifier.citationIbiyeye, R., Sulaimon, F., Imam, A., Adana, M., Okesina, A., & Ajao, M. (2023). Phoenix dactylifera and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats. Nigerian Journal of Physiological Sciences, 38(1), 73-78. Published by Physiological Society of Nigeria. Available online at https://ojshostng.com/index.php/njphysiologicalsciences/issue/view/152 Scopus link: https://pubmed.ncbi.nlm.nih.gov/38243365/
dc.identifier.issn0794-859X
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16775
dc.language.isoen
dc.publisherPhysiological Society of Nigeria
dc.subjectglutamate toxicity
dc.subjectdentate gyrus
dc.subjectPhoenix dactylifera
dc.subjectoxidative stress
dc.subjectneurodegeneration
dc.titlePhoenix dactylifera and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats
dc.typeArticle

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