Phoenix dactylifera and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats
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Date
2023
Authors
Adana, M. Y.
Ibiyeye, R.
Sulaimon, F.
Imam, A.
Okesina, A.
Ajao, M.
Journal Title
Journal ISSN
Volume Title
Publisher
Physiological Society of Nigeria
Abstract
Monosodium glutamate (MSG) has been known to cause neurodegeneration, due to its ability to trigger
excitotoxicity, and the hippocampus is one of the most affected regions. Therefore, Phoenix dactylifera (P. dactyliferaa )
and polyphenols were employed in this study to mitigate on the deleterious effect of monosodium glutamate on the dentate
gyrus of Wistar rats. Forty-eight male Wistar rats weighing between 120-150g was used for the study. The Wistar rats were
grouped into eight, (n=6). Groups 1-8 received 1.6mL/kg normal saline, 4000mg\kg monosodium glutamate for 7-days,
4000mg\kg monosodium glutamate for 7-days and 100mg\kg caffeic-acid for 14-days concurrently, 4000mg\kg monosodium
glutamate for 7-days and 100mg\kg P. dactyliferaa for 14-days concurrently, 4000mg\kg monosodium glutamate for 7-days
and 100mg\kg luteolin for 14-days concurrently, 100mg\kg. caffeic-acid for 14-days followed by 4000mg\kg monosodium
glutamate for 7-days, 100mg\kg P. dactyliferaa for 14-days followed by 4000mg\kg monosodium glutamate for 7-days and
100mg\kg luteolin for 14-days followed by 4000mg\kg monosodium glutamate for 7-days respectively. After the treatments,
the rats underwent behavioural test (Y-maze test), and subsequently, the brain tissues were processed for histological
(Hematoxylin & Eosin stain) and biochemical (superoxide dismustase, glutathione peroxidase and malondialdehyde)
analyses. The activities of P. dactyliferaa and polyphenols ameliorated the deleterious effect of monosodium glutamate,
through increased spontaneous alternation of the experimental animals, dominant matured granule cells of the dentate gyrus
and modulated the activities of superoxide dismutase, glutathione peroxidase and malondialdehyde in the male Wistar rats.
Therefore, this study revealed that P. dactyliferaa and polyphenols ameliorated monosodium glutamate toxicity in the
dentate gyrus of Wistar rats.
Description
Keywords
glutamate toxicity, dentate gyrus, Phoenix dactylifera, oxidative stress, neurodegeneration
Citation
Ibiyeye, R., Sulaimon, F., Imam, A., Adana, M., Okesina, A., & Ajao, M. (2023). Phoenix dactylifera and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats. Nigerian Journal of Physiological Sciences, 38(1), 73-78. Published by Physiological Society of Nigeria. Available online at https://ojshostng.com/index.php/njphysiologicalsciences/issue/view/152 Scopus link: https://pubmed.ncbi.nlm.nih.gov/38243365/