Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth

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dc.contributor.authorAyanniyi, R.O
dc.contributor.authorOjuade, F.I
dc.contributor.authorOlumoh-Abdul, H.A
dc.contributor.authorSalawu, M.K
dc.contributor.authorOlufadi-Ahmed, Haishat
dc.contributor.authorAdebisi-Jose, O. Gbemisola
dc.date.accessioned2021-06-01T10:55:13Z
dc.date.available2021-06-01T10:55:13Z
dc.date.issued2019-01
dc.description.abstractThe leaf extract of Turraea vogelii Hook. f. ex. Benth. is used in ethnomedicine for the management of pain and inflammation. Anti-nociceptive activity was determined using acetic acid-induced mouse writhing model. The anti￾inflammatory activity was investigated using in-vitro bovine serum albumin (BSA) denaturation assay and BSA-induced hind paw edema in rats. The extract (125-500 mg/kg) administered via the oral route produced a significant (p<0.005) inhibition of acetic acid-induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and diclofenac (10 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10-6 -1.0 µg/mL) inhibited protein denaturation with IC50values of (1.06 × 10-3 µg/mL and 2.58 × 10-3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62.5 mg/kg) significantly (p<0.05) inhibited BSA-induced paw edema in rats. The methanol leaf extract of T. vogelii has anti-nociceptive and anti-inflammatory activities. These findings justify the use of the plant in traditional medicine for the management of pain and inflammation.en_US
dc.description.sponsorshipSelf-fundeden_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5640
dc.language.isoenen_US
dc.publisherPakistan Journal of Pharmaceutical Scencesen_US
dc.relation.ispartofseries32, No.1(Suppl);241-245 2
dc.subjectAnti-nociceptiveen_US
dc.subjectanti-inflammatoryen_US
dc.subjectacetic aciden_US
dc.subjectbovine serum albuminen_US
dc.subjectTurraea vogellien_US
dc.titleEvaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benthen_US
dc.typeArticleen_US

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