Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth
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Date
2019-01
Journal Title
Journal ISSN
Volume Title
Publisher
Pakistan Journal of Pharmaceutical Scences
Abstract
The leaf extract of Turraea vogelii Hook. f. ex. Benth. is used in ethnomedicine for the management of pain
and inflammation. Anti-nociceptive activity was determined using acetic acid-induced mouse writhing model. The antiinflammatory activity was investigated using in-vitro bovine serum albumin (BSA) denaturation assay and BSA-induced
hind paw edema in rats. The extract (125-500 mg/kg) administered via the oral route produced a significant (p<0.005)
inhibition of acetic acid-induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and diclofenac (10
mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10-6
-1.0 µg/mL) inhibited protein denaturation with
IC50values of (1.06 × 10-3
µg/mL and 2.58 × 10-3
µg/mL) for extract and diclofenac respectively. Furthermore, the leaf
extract (62.5 mg/kg) significantly (p<0.05) inhibited BSA-induced paw edema in rats. The methanol leaf extract of T.
vogelii has anti-nociceptive and anti-inflammatory activities. These findings justify the use of the plant in traditional
medicine for the management of pain and inflammation.
Description
Keywords
Anti-nociceptive, anti-inflammatory, acetic acid, bovine serum albumin, Turraea vogelli