Synthesis, Characterization and Antimicrobial activities of some Mixed Ascorbic acid –Nicotinamide Metal Complexes
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Date
2015-01-25
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Faculty of Science, Bayero University Kano. Nigeria
Abstract
The present study aimed at synthesizing copper(II) and zinc(II) complexes of mixed ascorbic acid and nicotinamide and physiochemically characterize by solubility test, melting point, conductivity t e s t , i n f r a r e d , e l e c t r o n i c a n d p r o t o n n u c l e a r m a g n e t i c r e s o n a n c e t e c h n i q u e s . T h e r e s u l t o f t h e physiochemical studies indicated 1:1 stoichiometry and were supported by the spectroscopic data. T h e a n t i m i c r o b i a l a c t i v i t i e s o f t h e m i x e d c o m p l e x e s w e r e c a r r i e d o u t a g a i n s t B a c i l l u s s u b t i l i s , Escherichia coli, Staphylococcus aureus, Penicillum , spp Aspergillus flavus and Aspergillus niger. The result of the infrared data showed that ascorbi c acid coordinates through the oxygen of the carbonyl group and that of enolic C-2 hydroxyl grou p, while nicotinamide coordinates through the nitrogen atom of the pyridine ring. The result of t he antimicrobial studies showed that the mixed complexes have higher inhibitory activity than the original ligands against the tested bacteria and fu ngi species
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Keywords
Ascorbic acid, Nicotinamide, Synthesis, Antimicrobial, Complexes