Melatonin ameliorates ketoconazole-induced increase in thyroid function
| dc.contributor.author | Abdullateef Isiaka Alagbonsi, | |
| dc.contributor.author | Luqman Aribidesi Olayaki | |
| dc.contributor.author | Abdulrahim Halimat Amin | |
| dc.contributor.author | Mariam Titilayo Suleiman | |
| dc.contributor.author | Israel Bojuwade | |
| dc.contributor.author | Noah Adavize Omeiza | |
| dc.contributor.author | Sheu Oluwadare Sulaiman | |
| dc.date.accessioned | 2025-05-07T11:28:27Z | |
| dc.date.available | 2025-05-07T11:28:27Z | |
| dc.date.issued | 2020-03 | |
| dc.description.abstract | The antithyroid effect of ketoconazole has been reported. The secretion and action of melatonin in the thyroid gland are also known. However, the possible effect of melatonin on ketoconazole-induced antithyroid effect is unknown. Objective We sought to investigate the modulatory effect of ketoconazole and/or melatonin on thyroid function in female rats. Methods Groups 1-4 of female rats respectively underwent 14-day treatment with normal saline, 25 mg/kg ketoconazole, 4 mg/kg melatonin and 10 mg/kg melatonin. Groups 5 and 6 both received 14-day treatment with ketoconazole and were respectively treated with 4 mg/kg melatonin and 10 mg/kg melatonin simultaneously. Groups 7 and 8 respectively underwent 14-day pretreatment with 4 mg/kg melatonin and 10 mg/kg melatonin, followed by 14-day administration of ketoconazole to both groups. Groups 9 and 10 were both treated with ketoconazole for 14 days, followed by respective 14-day administration of 4 mg/kg melatonin and 10 mg/kg melatonin. Results TSH, T3, T4, and iodine concentrations were increased by separate administration of ketoconazole and either dose of melatonin when compared to control. However, pre-treatment or post-treatment of ketoconazole- treated rats with melatonin abolished the ketoconazole-induced increase in TSH, T3, T4, and iodine while co-administration of ketoconazole with melatonin caused no improvement in the ketoconazole-induced increase in TSH, T3, and T4 except iodine concentration. Conclusion Ketoconazole increased thyroid function, which was ameliorated by pre- or post-treatment with melatonin, possibly via modulation of the iodination process. | |
| dc.identifier.citation | Keywords: Iodine; Ketoconazole; Melatonin; Thyroid function; Toxicity | |
| dc.identifier.uri | https://dx.doi.org/10.4314/rjmhs.v3i1.2 | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/16314 | |
| dc.language.iso | en | |
| dc.publisher | Rwanda Journal of Medicine and Health Sciences | |
| dc.relation.ispartofseries | Vol.3 No.1; 3-10 | |
| dc.title | Melatonin ameliorates ketoconazole-induced increase in thyroid function | |
| dc.type | Article |