Melatonin ameliorates ketoconazole-induced increase in thyroid function
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Date
2020-03
Journal Title
Journal ISSN
Volume Title
Publisher
Rwanda Journal of Medicine and Health Sciences
Abstract
The antithyroid effect of ketoconazole has been reported. The secretion and action of melatonin in the thyroid
gland are also known. However, the possible effect of melatonin on ketoconazole-induced antithyroid effect
is unknown.
Objective
We sought to investigate the modulatory effect of ketoconazole and/or melatonin on thyroid function in
female rats.
Methods
Groups 1-4 of female rats respectively underwent 14-day treatment with normal saline, 25 mg/kg
ketoconazole, 4 mg/kg melatonin and 10 mg/kg melatonin. Groups 5 and 6 both received 14-day treatment
with ketoconazole and were respectively treated with 4 mg/kg melatonin and 10 mg/kg melatonin
simultaneously. Groups 7 and 8 respectively underwent 14-day pretreatment with 4 mg/kg melatonin and
10 mg/kg melatonin, followed by 14-day administration of ketoconazole to both groups. Groups 9 and 10
were both treated with ketoconazole for 14 days, followed by respective 14-day administration of 4 mg/kg
melatonin and 10 mg/kg melatonin.
Results
TSH, T3, T4, and iodine concentrations were increased by separate administration of ketoconazole and either
dose of melatonin when compared to control. However, pre-treatment or post-treatment of ketoconazole-
treated rats with melatonin abolished the ketoconazole-induced increase in TSH, T3, T4, and iodine while
co-administration of ketoconazole with melatonin caused no improvement in the ketoconazole-induced
increase in TSH, T3, and T4 except iodine concentration.
Conclusion
Ketoconazole increased thyroid function, which was ameliorated by pre- or post-treatment with melatonin,
possibly via modulation of the iodination process.
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Keywords
Citation
Keywords: Iodine; Ketoconazole; Melatonin; Thyroid function; Toxicity