Cornsilk methanolic extract improves oxidative stress and inflammatory responses in rats excision wound model

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dc.contributor.authorOyabambi, A.O
dc.contributor.authorNafiu, A.B
dc.contributor.authorOkesina, A
dc.contributor.authorBabatunde, S.S
dc.contributor.authorDominic, E.K
dc.contributor.authorOreoluwa, D.O
dc.date.accessioned2021-06-09T09:18:40Z
dc.date.available2021-06-09T09:18:40Z
dc.date.issued2021
dc.description.abstractAnti-inflammatory and antioxidant activities of corn silk (Stigma maydis of Zea mays L.) extract were investigated in excision wound model. Twenty male Wistar rats (130-150g) were grouped into four (n=5/group): Control rats received 0.5 mL distilled water, the experimental groups received distilled water (0.5 mL), aqueous corn-silk extract (ACSE; 500 mg/kg) and methanolic corn-silk extract (MCSE; 500 mg/kg), twice/day orally, three weeks before and three weeks after they had 1.5 × 1.0 cm excision wound. Rats were sacrificed and blood was collected. Serum was separated while wound tissues were removed, homogenised and supernatant was stored. Antioxidant enzymes, malondialdehyde, hydroxyproline, cyclooxygenase-2 and NO were measured in wound tissues colorimetrically, while serum cytokines were measured using enzyme linked immunosorbent assay. MCSE significantly (p˂0.05) increased glutathione peroxidase, superoxide dismutase, catalase, hydroxyproline and total protein content but decreased significantly (p˂0.05) malondialdehyde, cyclooxygenase-2, IL-1β, TNF-α, and IFN-γ when compared with untreated wound. ACSE increased significantly (p<0.05) glutathione peroxidase and superoxide dismutase but decreased significantly (p<0.05) malondialdehyde and cyclooxygenase-2. However, it produced no significant effect on catalase, IL-1β, TNF-α, and IFN-γ when compared with untreated wound. MCSE attenuated oxidative and inflammatory responses in excision wound rat modelen_US
dc.description.sponsorshipNILen_US
dc.identifier.citationA.O. Oyabambi et. alen_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/6065
dc.language.isoenen_US
dc.publisherUniversity of Peradeniya, Sri Lanka.en_US
dc.relation.ispartofseries50(1);
dc.subjectCorn silk extracten_US
dc.subjectantioxidant enzymesen_US
dc.subjectantiinflammationen_US
dc.subjectcytokinesen_US
dc.subjectwound healingen_US
dc.titleCornsilk methanolic extract improves oxidative stress and inflammatory responses in rats excision wound modelen_US

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