Antimicrobial Screening of Bridelia ferruginea Benth (Euphorbiaceae) Stem Bark Extract in Dermatological Formulations

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Pharmaceutical research, development and Practices


Abstract The plantBridelia ferruginea Benth (Euphorbiaceae) has been known for its ethnomedicinal uses, some of which have been justified by scientific studies. Various forms of presentations such as decoction, powders have been used traditionally. None of these have been standardized to assure stability, safety, efficacy, and appropriate dose delivery. The aim of the present work was to develop an antimicrobial dermatological dosage formulation that will be useful in the treatment of various skin diseases. Extraction of the stem bark was carried out with boiled distilled water. The phytochemical constituent of the extract was determined. Thereafter, the extract was formulated into creams using vanishing cream base as a vehicle at concentrations of 2.5, 5.0, 7.5 and 10.0%w/w respectively. The formulation was evaluated for physical characteristics and then tested against selected organisms such as Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Trichophyton rubrum and Aspergillus nige rusing Gentamicin and Ketoconazole creams as reference compounds. The results showed the presence of flavonoids, saponin, tannins, anthraquinones, terpenoids and alkaloids as secondary metabolites. The creams gave favourable physical characteristics. The antimicrobial evaluation showed that the cream formulations (2.5, 5.0, 7.5, 10.0 %w/w) had inhibitory effect against organisms used. This inhibition was of increasing order across the concentration range of the formulations tested. The only exception was 2.5 %w/w concentration that did not show inhibitory activity against Pseudomonas aeruginosa. Cream formulations of the stem bark extracts of B. ferruginea exhibited favourable physical characteristics and promising antimicrobial activities, it could therefore be used in the treatment of certain skin infections.



Bridelia ferruginea, Creams, Antimicrobial, Organisms, Inhibition.