Effects of albendazole administration on the testicular histology of adult Wistar rats

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Date

2013

Journal Title

Journal ISSN

Volume Title

Publisher

Society of Experimental and Clinical Anatomist of Nigeria (JECA)

Abstract

The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains.Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in males

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Keywords

Albendazole, histology, testes, Wistar rats

Citation

Omotoso, et al.: Effects of albendazole on the testes

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