Effects of albendazole administration on the testicular histology of adult Wistar rats
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Date
2013
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Journal ISSN
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Publisher
Society of Experimental and Clinical Anatomist of Nigeria (JECA)
Abstract
The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar
rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While
animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg
respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about
24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological
consideration, using Haematoxylin and Eosin stains.Results: Varying degrees of histological changes were noticed in
the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion:
These structural distortions and degenerations of testicular tissues that occurred after albendazole administration
are dose-dependent, and could affect reproductive functions in males
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Keywords
Albendazole, histology, testes, Wistar rats
Citation
Omotoso, et al.: Effects of albendazole on the testes