Effects of albendazole administration on the testicular histology of adult Wistar rats

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dc.contributor.authorOmotoso, G.O
dc.contributor.authorAlabi, A.S
dc.contributor.authorOyabambi, A.O
dc.date.accessioned2021-06-09T09:15:40Z
dc.date.available2021-06-09T09:15:40Z
dc.date.issued2013
dc.description.abstractThe testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains.Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in malesen_US
dc.description.sponsorshipNILen_US
dc.identifier.citationOmotoso, et al.: Effects of albendazole on the testesen_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/6059
dc.language.isoenen_US
dc.publisherSociety of Experimental and Clinical Anatomist of Nigeria (JECA)en_US
dc.relation.ispartofseries12(2);50-52;
dc.subjectAlbendazoleen_US
dc.subjecthistologyen_US
dc.subjecttestesen_US
dc.subjectWistar ratsen_US
dc.titleEffects of albendazole administration on the testicular histology of adult Wistar ratsen_US

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