Effects of albendazole administration on the testicular histology of adult Wistar rats
dc.contributor.author | Omotoso, G.O | |
dc.contributor.author | Alabi, A.S | |
dc.contributor.author | Oyabambi, A.O | |
dc.date.accessioned | 2021-06-09T09:15:40Z | |
dc.date.available | 2021-06-09T09:15:40Z | |
dc.date.issued | 2013 | |
dc.description.abstract | The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains.Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in males | en_US |
dc.description.sponsorship | NIL | en_US |
dc.identifier.citation | Omotoso, et al.: Effects of albendazole on the testes | en_US |
dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/6059 | |
dc.language.iso | en | en_US |
dc.publisher | Society of Experimental and Clinical Anatomist of Nigeria (JECA) | en_US |
dc.relation.ispartofseries | 12(2);50-52; | |
dc.subject | Albendazole | en_US |
dc.subject | histology | en_US |
dc.subject | testes | en_US |
dc.subject | Wistar rats | en_US |
dc.title | Effects of albendazole administration on the testicular histology of adult Wistar rats | en_US |
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