Mupirocin Susceptibility of Methicillin-Resistant Staphylococcus aureus isolated from Nasal Carriers among Health Care Workers in Critical Units at The University of Ilorin Teaching Hospital, Ilorin, North Central Nigeria
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Date
2021-12
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Publisher
ASUU JOURNAL OF SCIENCE A Journal of Research and Development
Abstract
Mupirocin is a Topical Antimicrobial Agent with excellent anti-
staphylococcal and anti-streptococcal activity. Mupirocin resistance
of Methicillin Resistant S. aureus (MRSA) is a reported in some parts
of the world. The aim of the study was to determine the susceptibility
of Methicillin Resistant Staphylococcus aureus from nasal carriers
among Health Care Workers (HCWs) at the University of Ilorin
Teaching Hospital to Mupirocin. One hundred and twenty Health
Care Workers were selected. The demographic data of each of
participants was collected using a standardized questionnaire. Two
anterior nares swabs were taken from each of the 120 HCWs
selected. Altogether, 240 anterior nares swab samples were
collected. Identification of S. areus was done microscopically.
Detection of MRSA was done using cefoxitin disc (30μg) diffusion
method. Antimicrobial susceptibility Test was done by Kirby-Bauer
disc diffusion method using Mupirocin (5 μg), Mupirocin (200μg)
and other antibiotics. The E-Test was used to determine the Minimum
Inhibitory Concentration (MIC) of Mupirocin. Interpretations was
based on Clinical Laboratory Standards Institute. All the MRSA
isolates in this study were sensitive to Mupirocin. Of the 240 nasal
swabs collected from 120 HCWs, 150 swabs were isolated with S.
aureus, 75 (50.0%) were MRSA. Of the 120 HCWs, 46 (38.3%) were
carriers of MRSA. Potters (71.4%), Nurses (41.9%) and Doctors
(37.5%) were the predominant carriers. All antibiotics used, except
Mupirocin had some resistance to MRSA. The 100% susceptibility of
MRSA to Mupirocin suggests it could be a drug of choice for nasal
decolonization of MRSAin at risk populations.
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Keywords
Citation
Methicillin-Resistant Staphylococcus aureus (MRSA); Nasal Carriers; Mupirocin Susceptiblity; Health Care Workers.