Mupirocin Susceptibility of Methicillin-Resistant Staphylococcus aureus isolated from Nasal Carriers among Health Care Workers in Critical Units at The University of Ilorin Teaching Hospital, Ilorin, North Central Nigeria

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dc.contributor.authorAmase Nyamngee
dc.contributor.authorAbdullahi Mohammed Ndagidzuru
dc.contributor.authorNwabuisi Charles
dc.contributor.authorIkpe Raphael Terlumun
dc.date.accessioned2025-05-09T15:09:37Z
dc.date.available2025-05-09T15:09:37Z
dc.date.issued2021-12
dc.description.abstractMupirocin is a Topical Antimicrobial Agent with excellent anti- staphylococcal and anti-streptococcal activity. Mupirocin resistance of Methicillin Resistant S. aureus (MRSA) is a reported in some parts of the world. The aim of the study was to determine the susceptibility of Methicillin Resistant Staphylococcus aureus from nasal carriers among Health Care Workers (HCWs) at the University of Ilorin Teaching Hospital to Mupirocin. One hundred and twenty Health Care Workers were selected. The demographic data of each of participants was collected using a standardized questionnaire. Two anterior nares swabs were taken from each of the 120 HCWs selected. Altogether, 240 anterior nares swab samples were collected. Identification of S. areus was done microscopically. Detection of MRSA was done using cefoxitin disc (30μg) diffusion method. Antimicrobial susceptibility Test was done by Kirby-Bauer disc diffusion method using Mupirocin (5 μg), Mupirocin (200μg) and other antibiotics. The E-Test was used to determine the Minimum Inhibitory Concentration (MIC) of Mupirocin. Interpretations was based on Clinical Laboratory Standards Institute. All the MRSA isolates in this study were sensitive to Mupirocin. Of the 240 nasal swabs collected from 120 HCWs, 150 swabs were isolated with S. aureus, 75 (50.0%) were MRSA. Of the 120 HCWs, 46 (38.3%) were carriers of MRSA. Potters (71.4%), Nurses (41.9%) and Doctors (37.5%) were the predominant carriers. All antibiotics used, except Mupirocin had some resistance to MRSA. The 100% susceptibility of MRSA to Mupirocin suggests it could be a drug of choice for nasal decolonization of MRSAin at risk populations.
dc.identifier.citationMethicillin-Resistant Staphylococcus aureus (MRSA); Nasal Carriers; Mupirocin Susceptiblity; Health Care Workers.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16562
dc.language.isoen
dc.publisherASUU JOURNAL OF SCIENCE A Journal of Research and Development
dc.relation.ispartofseriesVol. 8 No. 1 & 2; 229-245
dc.titleMupirocin Susceptibility of Methicillin-Resistant Staphylococcus aureus isolated from Nasal Carriers among Health Care Workers in Critical Units at The University of Ilorin Teaching Hospital, Ilorin, North Central Nigeria
dc.typeArticle

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