Ivermectin Protects Against Monosodium Glutamate-Induced Excitotoxicity in the Rat

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dc.contributor.authorArise, R.O.
dc.contributor.authorArise, A.k.
dc.contributor.authorMalomo, S.O
dc.contributor.authorOyewole, I.O.
dc.date.accessioned2018-06-08T10:38:55Z
dc.date.available2018-06-08T10:38:55Z
dc.date.issued2013
dc.description.abstractMonosodium glutamate (MSG), an established excitotoxic food additive, has been found to induce oxidative stress in all tissues. To examine the protective effects of ivermectin on MSG-induced excitotoxicity, twenty-eight male albino rats were randomized into group 1, the control, which received 1 ml oral administration of distilled water; group 2, aqueous solution of MSG (4 mg/kg body weight/day); group 3, co-administered with the same dose of MSG and 0.4 mg/kg body weight of ivermectin; group 4,orally administered with the same dose of MSG for 2 weeks after which ivermectin was orally administered for 1 week. Oral administration of MSG for 21 days, and for only 14 days followed by oral administration of ivermectin for 7 days, significantly increased (p<0.05) glutathione-Stransferase, nitric oxide synthase, superoxide dismutase and catalase activities as well as malondialdehyde and intracellular Ca2+ concentrations while the activities of Na+-K+- ATPase, Ca2+- Mg2+-ATPase, acid phosphatase and alkaline phosphatase were significantly reduced (p< 0.05) when compared with the control. However, co administration of MSG and ivermectin for 21 days showed no significant difference (p>0.05) in all the parameters investigated when compared with the control. This result suggests that ivermectin may exert protection against MSG-induced excitotoxicity in rats.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/433
dc.language.isoenen_US
dc.publisherSociety of Ecotoxicology and Environmental Safetyen_US
dc.subjectMonosodium glutamate,en_US
dc.subjectivermectin,en_US
dc.subjectexcitotoxicity,en_US
dc.subjectoxidative stressen_US
dc.titleIvermectin Protects Against Monosodium Glutamate-Induced Excitotoxicity in the Raten_US
dc.typeArticleen_US

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