Ivermectin Protects Against Monosodium Glutamate-Induced Excitotoxicity in the Rat

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Society of Ecotoxicology and Environmental Safety


Monosodium glutamate (MSG), an established excitotoxic food additive, has been found to induce oxidative stress in all tissues. To examine the protective effects of ivermectin on MSG-induced excitotoxicity, twenty-eight male albino rats were randomized into group 1, the control, which received 1 ml oral administration of distilled water; group 2, aqueous solution of MSG (4 mg/kg body weight/day); group 3, co-administered with the same dose of MSG and 0.4 mg/kg body weight of ivermectin; group 4,orally administered with the same dose of MSG for 2 weeks after which ivermectin was orally administered for 1 week. Oral administration of MSG for 21 days, and for only 14 days followed by oral administration of ivermectin for 7 days, significantly increased (p<0.05) glutathione-Stransferase, nitric oxide synthase, superoxide dismutase and catalase activities as well as malondialdehyde and intracellular Ca2+ concentrations while the activities of Na+-K+- ATPase, Ca2+- Mg2+-ATPase, acid phosphatase and alkaline phosphatase were significantly reduced (p< 0.05) when compared with the control. However, co administration of MSG and ivermectin for 21 days showed no significant difference (p>0.05) in all the parameters investigated when compared with the control. This result suggests that ivermectin may exert protection against MSG-induced excitotoxicity in rats.



Monosodium glutamate,, ivermectin,, excitotoxicity,, oxidative stress