Spondias mombin promotes gastric mucosa and lipid profile status in gastric ulceration
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Date
2014-08-10
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Publisher
Brazilian Society of Anatomy and Pan-American Association of Anatomy
Abstract
Introduction: Spondias mombin has been reported to possess medicinal properties. Material and
Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received
physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to
rats of Groups II – VI. Four hours after administrations of the ulcerogen; rats of Groups III – VI were
treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark
extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1
(Group II) and 5 (Groups I and III – VI); stomach and liver samples were removed for evaluations of gastric
acidity, histo-pathological and lipid profile status. Results: Analyses of gastric acidity and lipid profile status
in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05)
of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high
density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III – VI. Histopathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III – VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin – induced gastric ulceration.
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Keywords
spondias mombin, indomethacin, stomach, ulceration, rats