Spondias mombin promotes gastric mucosa and lipid profile status in gastric ulceration

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dc.contributor.authorAkinlolu, A. A.
dc.contributor.authorGhazali, K. O.
dc.contributor.authorAmeen, Mubarak
dc.contributor.authorOdewabi, A. O.
dc.date.accessioned2021-05-27T12:33:45Z
dc.date.available2021-05-27T12:33:45Z
dc.date.issued2014-08-10
dc.description.abstractIntroduction: Spondias mombin has been reported to possess medicinal properties. Material and Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II – VI. Four hours after administrations of the ulcerogen; rats of Groups III – VI were treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1 (Group II) and 5 (Groups I and III – VI); stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and lipid profile status. Results: Analyses of gastric acidity and lipid profile status in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05) of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III – VI. Histopathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III – VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin – induced gastric ulceration.en_US
dc.identifier.issn2177-0298
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5492
dc.language.isoenen_US
dc.publisherBrazilian Society of Anatomy and Pan-American Association of Anatomyen_US
dc.subjectspondias mombinen_US
dc.subjectindomethacinen_US
dc.subjectstomachen_US
dc.subjectulcerationen_US
dc.subjectratsen_US
dc.titleSpondias mombin promotes gastric mucosa and lipid profile status in gastric ulcerationen_US
dc.title.alternativeJournal of Morpholological Scienceen_US
dc.typeArticleen_US

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