Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats

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dc.contributor.authorAdeyanju, Oluwaseun
dc.contributor.authorBadejogbin, Olabimpe
dc.contributor.authorAreola, Damilare Emmanuel
dc.contributor.authorOlaniyi, Kehinde
dc.contributor.authorDibia, Chinaza
dc.contributor.authorSoetan, Olaniyi
dc.contributor.authorOniyide, Adesola
dc.contributor.authorMichael, Olugbenga
dc.contributor.authorOlatunji, Lawrence Aderemi
dc.contributor.authorSoladoye, Ayodele
dc.date.accessioned2026-01-22T10:04:26Z
dc.date.available2026-01-22T10:04:26Z
dc.date.issued2020-11-01
dc.description.abstractHigh fat diet (HFD) is a risk factor for metabolic syndrome which is characterized by overt glucose dysmetab olism and tissue derangement. The liver and pancreas are important metabolic tissues with anatomical proximity sharing splanchnic and mesenteric circulation but it is unclear whether, there is an associated metabolic status between the two organs in health and disease. Uric acid (UA) hypersecretion and ectopic lipid accumulation are characteristic pathophysiology of an array of non-communicable diseases. Sodium butyrate (BUT) is reputed for therapeutic roles in metabolic derangement. Therefore, the present study investigated synchrony in hepatic and pancreatic UA and lipid metabolic status in HFD-induced glucose dysregulation and probed the beneficial effects of BUT. Twenty-four female Wistar rats were treated with normal rat chow and distilled water (po) or sodium butyrate (200 mg/kg; po) or high fat diet and distilled water (po) or high fat diet and sodium butyrate. Results showed that HFD increased plasma, pancreatic and hepatic triglyceride, triglyceride-glucose index, malondial dehyde, uric acid (UA), lactate dehydrogenase but reduced glucose-6-phosphate dehydrogenase. Histological analysis revealed hepatic and pancreatic architectural derangement and cellular degeneration in HFD-fed ani mals. However, BUT reversed the HFD-induced systemic, pancreatic and hepatic synchronous dysmetabolism with evidence of improved histology. HFD-induced lipid and UA alterations were synchronous in the pancreas and liver. BUT elicits beneficial effects on systemic and tissue HFD-induced deleterious metabolic changes which were synchronized in pancreas and liver of rats.
dc.description.sponsorshipThis study was not funded by any grant body but the authors involved.
dc.identifier.citationAdeyanju, O.A., Badejogbin, O.C., Areola, D.E., Olaniyi, K.S., Dibia, C., Soetan, O.A., Oniyide, A.A., Michael, O.S., Olatunji, L.A., & Soladoye, A.O. (2020). Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats. Biomedicine and Pharmacotherapy, 133, 110994, Published by Elsevier. Available online at: Biomedicine & Pharmacotherapy | Vol 133, January 2021 | ScienceDirect.com by Elsevier
dc.identifier.uri10.1016/j.biopha.2020.110994
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16907
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofseries133; 110994
dc.subjectPancreas
dc.subjectShort chain fatty acid
dc.subjectNAFLD
dc.subjectUric acid
dc.subjectHigh fat diet
dc.titleSodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats
dc.typeArticle

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