Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats
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Date
2020-11-01
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Publisher
Elsevier
Abstract
High fat diet (HFD) is a risk factor for metabolic syndrome which is characterized by overt glucose dysmetab olism and tissue derangement. The liver and pancreas are important metabolic tissues with anatomical proximity
sharing splanchnic and mesenteric circulation but it is unclear whether, there is an associated metabolic status
between the two organs in health and disease. Uric acid (UA) hypersecretion and ectopic lipid accumulation are
characteristic pathophysiology of an array of non-communicable diseases. Sodium butyrate (BUT) is reputed for
therapeutic roles in metabolic derangement. Therefore, the present study investigated synchrony in hepatic and
pancreatic UA and lipid metabolic status in HFD-induced glucose dysregulation and probed the beneficial effects
of BUT. Twenty-four female Wistar rats were treated with normal rat chow and distilled water (po) or sodium
butyrate (200 mg/kg; po) or high fat diet and distilled water (po) or high fat diet and sodium butyrate. Results
showed that HFD increased plasma, pancreatic and hepatic triglyceride, triglyceride-glucose index, malondial dehyde, uric acid (UA), lactate dehydrogenase but reduced glucose-6-phosphate dehydrogenase. Histological
analysis revealed hepatic and pancreatic architectural derangement and cellular degeneration in HFD-fed ani mals. However, BUT reversed the HFD-induced systemic, pancreatic and hepatic synchronous dysmetabolism
with evidence of improved histology. HFD-induced lipid and UA alterations were synchronous in the pancreas
and liver. BUT elicits beneficial effects on systemic and tissue HFD-induced deleterious metabolic changes which
were synchronized in pancreas and liver of rats.
Description
Keywords
Pancreas, Short chain fatty acid, NAFLD, Uric acid, High fat diet
Citation
Adeyanju, O.A., Badejogbin, O.C., Areola, D.E., Olaniyi, K.S., Dibia, C., Soetan, O.A., Oniyide, A.A., Michael, O.S., Olatunji, L.A., & Soladoye, A.O. (2020). Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats. Biomedicine and Pharmacotherapy, 133, 110994, Published by Elsevier. Available online at: Biomedicine & Pharmacotherapy | Vol 133, January 2021 | ScienceDirect.com by Elsevier