uprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

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dc.contributor.authorOmotoso, GO
dc.contributor.authorOlajide, OJ
dc.contributor.authorGbadamosi, IT
dc.contributor.authorAdebayo, JO
dc.contributor.authorEnaibe, BU
dc.contributor.authorAkinola, OB
dc.contributor.authorOwoyele, BV
dc.date.accessioned2019-10-31T11:41:10Z
dc.date.available2019-10-31T11:41:10Z
dc.date.issued2019-02-26
dc.description.abstractCuprizone-induced neurotoxicity has been employed to study the biology of remyelination in experimental models of multiple sclerosis. This study was aimed at determining the role of kolaviron, a biflavonoid from Garcinia kola, in mitigating the damaging effects of cuprizone on behaviour and the hippocampus. Twenty-four male albino mice aged 6–8 weeks were categorised into 4 equal groups: Group A (Control) received regular diet; Group B received 200 mg/kg/d of kolaviron in addition to their regular diet; Group C received 0.2% cuprizone diet only, while Group D received both kolaviron and cuprizone diet. The treatment lasted for 35 days after which behavioural tests (Morris water maze, Y maze and open field tests) were conducted and brain tissues were processed for histology, histochemistry (Nissl staining), immunohistochemistry (glial fibrillary acidic protein) and biochemistry (malondialdehyde, superoxide dismutase and glutathione peroxidase). Results showed that cuprizone toxicity led to weight loss, impairment in memory and exploratory drive, oxidative stress, chromatolysis and reactive astrocytosis; meanwhile administration of kolaviron prevented cuprizone-induced weight loss, memory decline, oxidative stress and neuromorphological alterations. In conclusion, administration of kolaviron might be useful in limiting the effects of cuprizone toxicity on the morphology and functions of the hippocampus.en_US
dc.description.sponsorshipThis work was supported by the Institutional-based Intervention Research Grant under the Tertiary Education Trust Fund through the University of Ilorin, Ilorin, Nigeria.en_US
dc.identifier.citationOmotoso, G.O., Olajide, O.J., Gbadamosi, I.T., Adebayo J.O., Enaibe, B.U., Akinola, O.B. & Owoyele, B.V. (2019): Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour. Heliyon. 5 (2019) e02102. https://www.ncbi.nlm.nih.gov/pubmed/31367687en_US
dc.identifier.urihttp://hdl.handle.net/123456789/3258
dc.language.isoenen_US
dc.publisherHeliyon, Elsevieren_US
dc.relation.ispartofseries5 (2019) e02102;
dc.subjectAnatomyen_US
dc.subjectBiochemistryen_US
dc.subjectCell biologyen_US
dc.subjectNeuroscienceen_US
dc.subjectStructural biologyen_US
dc.titleuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviouren_US
dc.typeArticleen_US

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