Anti-Cancer and Tissue-Neuroprotective Potentials of Moringa oleifera and Musa sapientum Against In-Vivo Cadmium ChlorideInduced Skin Toxicity

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dc.contributor.authorAkinlolu, A. A.
dc.contributor.authorEbito, G.
dc.contributor.authorAmeen, M.
dc.contributor.authorNnaemeka, N.
dc.contributor.authorAkindele, R.
dc.contributor.authorFagbohunka, B.
dc.date.accessioned2023-08-04T10:57:18Z
dc.date.available2023-08-04T10:57:18Z
dc.date.issued2023-08-01
dc.description.abstractBackground: Cadmium is an established carcinogen. Cadmium exposure resulted in skin carcinogenesis in rats. Furthermore, neurotransmitter-cancer interaction, tissue innervation, and angiogenesis influence cancer prognosis, metastasis, and survival. In this study, we evaluated the anticancer and neuro-protective potentials of MO11 (isolated from Moringa oleifera leaves) and MS06 (isolated from Musa sapientum suckers) against in-vivo Cadmium Chloride (CdCl2)- induced skin toxicity. Methods: Twenty-four adult male wistar rats were randomly divided into six groups (n = 4). Group 1 was control. Groups 2-4 and 6 received a single intraperitoneal administration of 1.5 mg/kg CdCl2 on Day 1. Thereafter, Groups 3, 4, and 6 were post-treated with 15 mg/kg MO11, 15 mg/kg MO11 + 7 mg/kg MS06, and 3.35 mg/kg Doxorubicin respectively (Days 1-17). Group 5 received an olive oil dose (vehicle) (Days 1-17). Skin histopathology and tissue-enzyme-linked-immunosorbent assays (Tissue-ELISA) of neurotransmitters (Dopamine and Glutamate), biomarkers of myelination (Myelin Basic Protein), drug metabolism and carcinogenesis (Cytochrome-p450), apoptosis (Caspase-3 and p53), proliferation (Ki67), and angiogenesis (sVEGFR) were evaluated in skin homogenates. Data were statistically analyzed using the Mann-Whitney-U test at P ≤ 0.05. Results: Histopathological analyses revealed normal skin histology (Groups 3 and 4), mild skin histo-alterations (Group 6), and gross skin histopathological alterations (Group 2). Tissue-ELISA analyses showed upregulations of dopamine, Glutamate and Cytochrome-p450, but downregulations of Myelin Basic Protein, Caspase-3, Ki67, p53, and sVEGFR in groups 3, 4, and 6, compared with group 2. MO11 and MS06 achieved better anticancer effects than doxorubicin. Conclusion: Overall, MO11 and MS06 possess histo-protective, neuro-protective, re-myelination, anti-proliferation, anti-angiogenesis, and anti-cancer potentials.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11663
dc.language.isoenen_US
dc.publisherAssociation of Anatomical Societies of Africaen_US
dc.subjectanticancer potentialsen_US
dc.subjectanti-toxic principlesen_US
dc.subjectcadmiumen_US
dc.subjectmoringa oleiferaen_US
dc.subjectmusa sapientumen_US
dc.subjectskin carcinogenesisen_US
dc.titleAnti-Cancer and Tissue-Neuroprotective Potentials of Moringa oleifera and Musa sapientum Against In-Vivo Cadmium ChlorideInduced Skin Toxicityen_US
dc.typeArticleen_US

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