Disseminated tuberculosis in a Nigerian adolescent with Linear IgA Bullous Dermatosis: A case report and review of the literature.
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2022-06
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Abstract
Linear IgA bullous dermatosis (LABD) is an auto-immune
disease affecting young children and adults, characterized by
the linear deposition of IgA at the basement membrane zone
with resultant complement activation and a cascade of immune
reactions. There is a loss of adhesion at the dermo-epidermal
junction and subsequent blister formation. It is a rare disease
that has a good prognosis with adequate therapy. However,
the underlying depressed immunity associated with the disease
may expose them to such infections as tuberculosis. We report
the case of an 11-years-old Nigerian female adolescent with
LABD, diagnosed at the age of four years but defaulted on
fol low-up, who developed disseminated tuberculosis
(pulmonary, lymph nodes, abdominal and pericardial effusion)
seven years after the appearance of the initial blistering skin
lesions. She commenced anti-tuberculosis drugs, steroids, and
a tube pericardiostomy for the pericardial effusion. Dapsone
was initiated for the LABD during the continuation phase of
anti-tuberculosis therapy, with subsequent disappearance of
the skin rash within two weeks. WAJM 2022; 39(6): 646–
650.
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Gobir, A.A., Ariyibi, S.O., Ibraheem, R.M., Johnson, A.R., Abdulkadir, M.B., Katibi, O.S, Adeoye, P.O., Udoh, E.A, Ilesanmi, O.N., & Folaranmi, O.O. (2022): Disseminated tuberculosis in a Nigerian adolescent with Linear IgA Bullous Dermatosis: A case report and review of the literature. West African Journal of Medicine, 39(6), 646-650.