Impact of in situ granulation and temperature quenching on crystal habit and micromeritic properties of ibuprofen-cationic dextran conjugate crystanules
| dc.contributor.author | Abioye, Amos Olusegun | |
| dc.contributor.author | Kola-Mustapha, Adeola | |
| dc.contributor.author | Ruparelia, Ketan | |
| dc.date.accessioned | 2018-02-21T11:44:10Z | |
| dc.date.available | 2018-02-21T11:44:10Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Ibuprofen was recrystallized in the presence of aqueous solution of cationic dextran derivative, Diethylaminoethyl Dextran (Ddex) using the melt in-situ granulation-crystallization technique in order to produce a stable amorphous ibuprofen-Ddex conjugates with improved morphological, micromeritic and thermo-analytical characteristics without the use of organic solvent. Ddex was used in this study because of its ability to form conjugates with various drug molecules and enhance their physicochemical characteristics and therapeutic activities. Cationic dextrans are also biocompatible and biodegradable. Mechanism of conjugation as well as the impact of conjugation on the ibuprofen crystal habit was investigated. Gaussian type normal particle size distribution was obtained and the size of the crystals in the crystanule conjugates decreased steadily, with increasing concentration of Ddex, to a minimum of 480 nm (440 folds reduction, p < 0.05, n = 20) at Ddex molar concentration of 0.01M. FT-IR spectra showed electrostatic interaction and hydrogen bonding between ibuprofen and Ddex which was confirmed with the 1H NMR and 13H NMR spectra. DSC curves exhibited single peaks from the binary ibuprofen-Ddex conjugate crystanules suggesting compatibility and formulation of an eutectic product. The conjugate crystanules showed broad and diffuse endothermic peaks with a glass transition temperature (Tg) 58.3 and 59.14 °C at Ddex molar concentrations of 1.56 X 10-4 and 3.125 X 10-4 mM respectively confirming the existence of ibuprofen-Ddex crystanule conjugates in amorphous state. Higher concentrations of Ddex decreased Tg steadily. TGA curves showed first order degradation at low molar concentrations of Ddex up to 3.125 X 10-4 mM which coincides with the critical granular concentration of the crystanules with higher concentrations exhibited second order degradation profile. This study provides the basis for the development of stable amorphous drug-polymer conjugates with potential practical application in controlled and extended drug release formulations | en_US |
| dc.identifier.citation | 11 | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/103 | |
| dc.language.iso | en | en_US |
| dc.publisher | International Journal of Pharmaceutics | en_US |
| dc.subject | Ibuprofen-Diethylaminoethyl Dextran conjugates, in situ granulation-crystallization, temperature quenching, crystanules, crystal habit, micromeritics | en_US |
| dc.title | Impact of in situ granulation and temperature quenching on crystal habit and micromeritic properties of ibuprofen-cationic dextran conjugate crystanules | en_US |
| dc.type | Article | en_US |