EXTRACT OF Morinda lucida LEAF RESCUES HYPOGLYCAEMIC AND DYSLIPIDAEMIC CONDITIONS IN Plasmodium berghei INFECTED MICE

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dc.contributor.authorABDULKAREEM ADAM OLAITAN
dc.contributor.authorBABAMALE ABDULKAREEM OLAREWAJU
dc.contributor.authorANIFOWOSHE
dc.contributor.authorOPEYEMI OLUFUNKE ADENIKE
dc.contributor.authorOLORIEGBE NUSIRAT
dc.contributor.authorADAMOLEKUN COMFORT
dc.contributor.authorADETULA SAMSON
dc.contributor.authorALA ADEOLA ADEFOLUKE
dc.date.accessioned2025-04-27T11:55:56Z
dc.date.available2025-04-27T11:55:56Z
dc.date.issued2022
dc.description.abstractIncreasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important. In this study, we investigated the anti hypoglycaemic and anti-hyperlipidaemic effects of aqueous extract of Morinda lucida leaf in Plasmodium berghei infected mice. Twenty-five mice were randomly grouped into five: Uninfected, infected-untreated, chloroquine (20 mg/kg, per oral), and extract-treated (400 mg/kg and 800 mg/kg, respectively, per oral) groups. Fasting blood glucose was measured before parasite inoculation and after the last treatment. Blood was collected for lipid profile assay at the end of the 4-day treatment. Our results revealed that both chloroquine and the extract lowered parasite growth (p <0.05), while chloroquine and 400 mg/kg of the extract improved blood glucose in Plasmodium berghei-infection. More so, all the treated groups showed attenuated Plasmodium berghei-induced dyslipidaemia, with 400 mg/kg of the extract exhibiting better efficacy. Therefore, this study suggests that Morinda lucida leaf extract can be harnessed as a therapeutic regimen for improved malaria treatments and associated complications. Further study is recommended to elucidate the mechanism of anti-hypoglycaemic and anti-hyperlipidaemic activities of the extract and the possible bioactive compound(s) involved.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15467
dc.titleEXTRACT OF Morinda lucida LEAF RESCUES HYPOGLYCAEMIC AND DYSLIPIDAEMIC CONDITIONS IN Plasmodium berghei INFECTED MICE

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