EXTRACT OF Morinda lucida LEAF RESCUES HYPOGLYCAEMIC AND DYSLIPIDAEMIC CONDITIONS IN Plasmodium berghei INFECTED MICE
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Date
2022
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Abstract
Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into
alternative therapy to mitigate malaria-associated damages is important. In this study, we investigated the anti
hypoglycaemic and anti-hyperlipidaemic effects of aqueous extract of Morinda lucida leaf in Plasmodium berghei
infected mice. Twenty-five mice were randomly grouped into five: Uninfected, infected-untreated, chloroquine (20
mg/kg, per oral), and extract-treated (400 mg/kg and 800 mg/kg, respectively, per oral) groups. Fasting blood
glucose was measured before parasite inoculation and after the last treatment. Blood was collected for lipid profile
assay at the end of the 4-day treatment. Our results revealed that both chloroquine and the extract lowered
parasite growth (p <0.05), while chloroquine and 400 mg/kg of the extract improved blood glucose in Plasmodium
berghei-infection. More so, all the treated groups showed attenuated Plasmodium berghei-induced dyslipidaemia,
with 400 mg/kg of the extract exhibiting better efficacy. Therefore, this study suggests that Morinda lucida leaf
extract can be harnessed as a therapeutic regimen for improved malaria treatments and associated complications.
Further study is recommended to elucidate the mechanism of anti-hypoglycaemic and anti-hyperlipidaemic
activities of the extract and the possible bioactive compound(s) involved.