Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus‐induced renal injury in male Wistar rats
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Date
2024-09-30
Authors
Halimat Amin Abdulrahim
Emmanuel Aduragbemi Owootori
Adeyemi Fatai Odetayo
Joshua Damrah Bulus
Fatimoh Bolanle Jimoh
Emmanuel Oluwamuyiwa Gabriel
Iyanu Feranmi Odiete
Luqman Aribidesi Olayaki
Journal Title
Journal ISSN
Volume Title
Publisher
Naunyn-Schmiedeberg's Archives of Pharmacology
Abstract
Diabetic kidney disease is a major microvascular diabetes mellitus (DM) complication clinically associated with a gradual
renal function decline. Although metformin is a common drug for managing DM, however, monotherapy treatment with any
antidiabetic drug will necessitate dosage increment since type 2 DM (T2DM) deteriorates over time due to the increasing
pancreatic β-cell dysfunction and will eventually require a combination therapy approach with another antidiabetic medica-
tion. Vitamin D is a food supplement that has been proven to have antidiabetic and reno-protective activities. Hence, we
explore the combination of vitamin D and metformin on T2DM-induced renal dysfunction. Thirty male Wistar rats were
randomized into fve (5) groups: control, diabetes untreated, diabetics treated with metformin, vitamin D, and vitamin
D+metformin. Vitamin D and metformin signifcantly reversed DM-induced hyperglycemia, electrolyte imbalance, and
dyslipidemia. Also, vitamin D and metformin reversed T2DM-induced increase in serum creatinine and urea and renal
lactate, LDH, and oxido-infammatory response. These observed alterations were accompanied by an increase in proton
pump activities and modulation of Nrf2/Nf-κB and XO/UA signaling. This study revealed that vitamin D and/or metformin
ameliorated T2DM-induced renal injury.
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Citation
Diabetes mellitus · Diabetic kidney disease · Electrolyte imbalance · Proton pump dysfunction · Vitamin D