Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus‐induced renal injury in male Wistar rats

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dc.contributor.authorHalimat Amin Abdulrahim
dc.contributor.authorEmmanuel Aduragbemi Owootori
dc.contributor.authorAdeyemi Fatai Odetayo
dc.contributor.authorJoshua Damrah Bulus
dc.contributor.authorFatimoh Bolanle Jimoh
dc.contributor.authorEmmanuel Oluwamuyiwa Gabriel
dc.contributor.authorIyanu Feranmi Odiete
dc.contributor.authorLuqman Aribidesi Olayaki
dc.date.accessioned2025-04-16T09:47:46Z
dc.date.available2025-04-16T09:47:46Z
dc.date.issued2024-09-30
dc.description.abstractDiabetic kidney disease is a major microvascular diabetes mellitus (DM) complication clinically associated with a gradual renal function decline. Although metformin is a common drug for managing DM, however, monotherapy treatment with any antidiabetic drug will necessitate dosage increment since type 2 DM (T2DM) deteriorates over time due to the increasing pancreatic β-cell dysfunction and will eventually require a combination therapy approach with another antidiabetic medica- tion. Vitamin D is a food supplement that has been proven to have antidiabetic and reno-protective activities. Hence, we explore the combination of vitamin D and metformin on T2DM-induced renal dysfunction. Thirty male Wistar rats were randomized into fve (5) groups: control, diabetes untreated, diabetics treated with metformin, vitamin D, and vitamin D+metformin. Vitamin D and metformin signifcantly reversed DM-induced hyperglycemia, electrolyte imbalance, and dyslipidemia. Also, vitamin D and metformin reversed T2DM-induced increase in serum creatinine and urea and renal lactate, LDH, and oxido-infammatory response. These observed alterations were accompanied by an increase in proton pump activities and modulation of Nrf2/Nf-κB and XO/UA signaling. This study revealed that vitamin D and/or metformin ameliorated T2DM-induced renal injury.
dc.identifier.citationDiabetes mellitus · Diabetic kidney disease · Electrolyte imbalance · Proton pump dysfunction · Vitamin D
dc.identifier.urihttps://doi.org/10.1007/s00210-024-03478-w
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15060
dc.language.isoen
dc.publisherNaunyn-Schmiedeberg's Archives of Pharmacology
dc.relation.ispartofseriesVolume 398,; 3133–3146
dc.titleMetformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus‐induced renal injury in male Wistar rats
dc.typeArticle

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