Antioxidant and cytotoxicity of β-Amyrin acetate fraction from Bridellia ferruginea Leaves.

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dc.contributor.authorFabiyi, O.A
dc.contributor.authorAtolani, O
dc.contributor.authorAdeyemi, O.S
dc.contributor.authorOlatunji, G.A
dc.date.accessioned2023-06-13T09:23:05Z
dc.date.available2023-06-13T09:23:05Z
dc.date.issued2012
dc.descriptionAntioxidant and Cytotoxicity articleen_US
dc.description.abstractObjective: The objective of this work was to determine the beta-amyrin acetate fraction in leave extract of Bridelia ferruginea and evaluate for its antioxidant and cytotoxicity potentials. Methods: The dried and pulverized leaves of Bridelia ferruginea was extracted with hexane and then with ethyl acetate. The concentrated ethylacetate extract subjected to silica gel column chromatography and eluted with a mixture of equal volume of hexane and dichloromethane afforded two major fractions. The more polar fraction was concentrated and subjected to GCMS analysis which afforded the steroid, 12-Oleanen-3yl acetate commonly known as beta-amyrin acetate (66.14%). Its ability to act as a scavenger of DPPH radical and its cytotoxicity potential based on brine shrimp assay were investigated. Results: The DPPH antioxidant assay revealed that the fraction had a higher antioxidant potential with an IC50 value of 158.2毺g/mL relative to gallic acid which had IC50 of 201.1 毺g/mL. The cytotoxicity assay using the brine shrimp a gave LC 50 values of 319 and 5.86 毺g/mL for acute and lethal doses respectively indicating extreme toxicity when compared to reference drug, cyclophosphamide which had LC50 value of 2506 毺 g/mL. Conclusions: Thus, the beta-amyrin acetate has been identified for the first time in the leave of Bridelia ferruginea. The data here suggest that the beta-amyrin acetate fraction of the leave of Bridelia ferruginea could be further explored in biological profiling requiring antioxidant and cytotoxic dependent therapeutics as the plant could be a viable source of antioxidant and cytotoxic agents in cancer chemotherapy in the near futureen_US
dc.description.sponsorshipNoneen_US
dc.identifier.citationFabiyi, O.A., Olubunmi Atolani, Oluyomi S Adeyemi and Gabriel Ademola Olatunji (2012). Antioxidant and cytotoxicity of β-Amyrin acetate fraction from Bridellia ferruginea Leaves. Journal of Tropical Biomedicine. S981-984.en_US
dc.identifier.uriAsian Pacific Journal of Tropical Biomedicine | Vol 2, Issue 2, Suppl, Pages S464-S1211 (February 2012) | ScienceDirect.com by Elsevier
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11078
dc.language.isoenen_US
dc.publisherAsian Pacific Journal of Tropical Biomedicine. Published by Elsevieren_US
dc.relation.ispartofseriesS981-984;S981-984
dc.subjectBrine Shrimp; beta-amyrin acetate;12-Oleanen-3yl acetate; steroid; antioxidanten_US
dc.titleAntioxidant and cytotoxicity of β-Amyrin acetate fraction from Bridellia ferruginea Leaves.en_US
dc.typeArticleen_US

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