Safety Evaluation and Antimalarial Effect of Mechanochemically Synthesized Trimethoprim-copper in Plasmodium bergei Infected Mice.
| dc.contributor.author | Arise, Rotimi, Olusanya | |
| dc.contributor.author | Tella, A.C | |
| dc.contributor.author | Akiode, O.S., Mustapha, I.K., Sunday-Nwaso, O.E., Oyegoke, R.A. & Muritala, H.F. | |
| dc.date.accessioned | 2023-04-11T08:21:44Z | |
| dc.date.available | 2023-04-11T08:21:44Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Antimalarials are central to any strategy for effective reduction of malaria-related mortality. Efficacy and safety of antimalarial medicines, as measured by their quality, are therefore essential in mitigating morbidity and reducing deaths. The mechanochemical synthesis and characterization of trimethoprim-copper complex and its antimalarial efficacy on Plasmodium berghei infected mice and toxicity evaluation were investigated by evaluating percentage parasitemia and chemosuppresive effect of the drugs on Plasmodium berghei infected mice, status Derivatization of trimethoprim with copper enhanced the activity of the drug by significantly (p<0.05) improving the suppression of parasitemia in established infection when compared with the controls. Trimethoprim-copper complex demonstrated to be more efficacious than pure trimethoprim while chloroquine was most efficacious in malaria parasite clearance. Administration of trimethoprim, trimethoprim-copper complex and chloroquine to mice for seven days caused significant increase (p<0.05) in the activities of alkaline and acid phosphatases in the liver, kidney and small intestine when compared with the control while a significant reduction (p<0.05) in the activities of alanine and aspartate aminotransferases, and lactate dehyrogenase were observed in the liver, kidney and small intestine when compared with the control. Also there was a significant decrease (p<0.05) Derivatization of trimethoprim with copper enhanced the activity of the drug by significantly (p<0.05) improving the suppression of parasitemia in established infection when compared with the controls. Trimethoprim-copper complex demonstrated to be more efficacious than pure trimethoprim while chloroquine was most efficacious in malaria parasite clearance. Administration of trimethoprim, trimethoprim-copper complex and chloroquine to mice for seven days caused significant increase (p<0.05) in the activities of alkaline and acid phosphatases in the liver, kidney and small intestine when compared with the control while a significant reduction (p<0.05) in the activities of alanine and aspartate aminotransferases, and lactate dehyrogenase were observed in the liver, kidney and small intestine when compared with the control. Also there was a significant decrease (p<0.05) Derivatization of trimethoprim with copper enhanced the activity of the drug by significantly (p<0.05) improving the suppression of parasitemia in established infection when compared with the controls. Trimethoprim-copper complex demonstrated to be more efficacious than pure trimethoprim while chloroquine was most efficacious in malaria parasite clearance. Administration of trimethoprim, trimethoprim-copper complex and chloroquine to mice for seven days caused significant increase (p<0.05) in the activities of alkaline and acid phosphatases in the liver, kidney and small intestine when compared with the control while a significant reduction (p<0.05) in the activities of alanine and aspartate aminotransferases, and lactate dehyrogenase were observed in the liver, kidney and small intestine when compared with the control. Also there was a significant decrease (p<0.05) | en_US |
| dc.identifier.citation | Tropical Journal of Health Sciences. 23 (3): 1-9, | en_US |
| dc.identifier.issn | 1117-4153 | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/9035 | |
| dc.language.iso | en | en_US |
| dc.publisher | College of Medicine, University of Ilorin. | en_US |
| dc.subject | Mechanochemical synthesis,antimalarial activity, mice, trimethoprim, safety | en_US |
| dc.title | Safety Evaluation and Antimalarial Effect of Mechanochemically Synthesized Trimethoprim-copper in Plasmodium bergei Infected Mice. | en_US |
| dc.type | Article | en_US |
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