Safety Evaluation and Antimalarial Effect of Mechanochemically Synthesized Trimethoprim-copper in Plasmodium bergei Infected Mice.
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
College of Medicine, University of Ilorin.
Abstract
Antimalarials are central to any strategy for
effective reduction of malaria-related mortality.
Efficacy and safety of antimalarial medicines, as
measured by their quality, are therefore essential in
mitigating morbidity and reducing deaths. The
mechanochemical synthesis and characterization of
trimethoprim-copper complex and its antimalarial
efficacy on Plasmodium berghei infected mice and
toxicity evaluation were investigated by evaluating
percentage parasitemia and chemosuppresive effect of
the drugs on Plasmodium berghei infected mice, status
Derivatization of trimethoprim with copper enhanced
the activity of the drug by significantly (p<0.05)
improving the suppression of parasitemia in
established infection when compared with the controls.
Trimethoprim-copper complex demonstrated to be
more efficacious than pure trimethoprim while
chloroquine was most efficacious in malaria parasite
clearance. Administration of trimethoprim,
trimethoprim-copper complex and chloroquine to mice
for seven days caused significant increase (p<0.05) in
the activities of alkaline and acid phosphatases in the
liver, kidney and small intestine when compared with the control while a significant reduction (p<0.05) in the activities of alanine and aspartate aminotransferases, and lactate dehyrogenase were observed in the liver, kidney and small intestine when compared with the control. Also there was a significant decrease (p<0.05) Derivatization of trimethoprim with copper enhanced
the activity of the drug by significantly (p<0.05)
improving the suppression of parasitemia in
established infection when compared with the controls.
Trimethoprim-copper complex demonstrated to be
more efficacious than pure trimethoprim while
chloroquine was most efficacious in malaria parasite
clearance. Administration of trimethoprim,
trimethoprim-copper complex and chloroquine to mice
for seven days caused significant increase (p<0.05) in
the activities of alkaline and acid phosphatases in the
liver, kidney and small intestine when compared with the control while a significant reduction (p<0.05) in the activities of alanine and aspartate aminotransferases, and lactate dehyrogenase were observed in the liver, kidney and small intestine when compared with the control. Also there was a significant decrease (p<0.05)
Derivatization of trimethoprim with copper enhanced
the activity of the drug by significantly (p<0.05)
improving the suppression of parasitemia in
established infection when compared with the controls.
Trimethoprim-copper complex demonstrated to be
more efficacious than pure trimethoprim while
chloroquine was most efficacious in malaria parasite
clearance. Administration of trimethoprim,
trimethoprim-copper complex and chloroquine to mice
for seven days caused significant increase (p<0.05) in
the activities of alkaline and acid phosphatases in the
liver, kidney and small intestine when compared with the control while a significant reduction (p<0.05) in the activities of alanine and aspartate aminotransferases, and lactate dehyrogenase were observed in the liver, kidney and small intestine when compared with the control. Also there was a significant decrease (p<0.05)
Description
Keywords
Mechanochemical synthesis,antimalarial activity, mice, trimethoprim, safety
Citation
Tropical Journal of Health Sciences. 23 (3): 1-9,