Assessment of serum protein profile in sickle cell disease

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dc.contributor.authorMunirudeen Ibrahim
dc.contributor.authorHafiz Abiodun Yakub
dc.contributor.authorWasiu O. Garuba
dc.contributor.authorTolulope Ogunniyi
dc.contributor.authorAbubakar Z. Lawal
dc.contributor.authorGodwin O. Adunmo
dc.contributor.authorKola A Ogunwale,
dc.contributor.authorAkeem O. Busari
dc.contributor.authorAbdulGafar N Popoola
dc.contributor.authorSuleiman I. Eleha
dc.contributor.authorAbdulrazak Nuhu
dc.contributor.authorMusbaudeen Ibrahim
dc.date.accessioned2025-05-03T16:01:25Z
dc.date.available2025-05-03T16:01:25Z
dc.date.issued2024-10
dc.description.abstractAbstract Background: Sickle Cell disease (SCD) is known to be caused by a mutation in the beta-globin gene of the hemoglobin that affects the red blood cells (RBCs) and is passed down through generations. This study was carried out to determine the effect of sickling of RBC on serum protein profile in SCD individuals. Methods: A case-controlled study was carried out among 80 patients. They were forty-five sickle cell disease individuals (HbSS) attend ing Children Specialist Hospital Ilorin and thirty-five healthy controls (HbAA). The levels of total protein and albumin were determined spectrophotometrically and serum protein electrophoresis (SPE) was carried out using cellulose acetate electrophoresis. Results: Significant hypoalbuminemia and hypergammaglobulinemia were observed in SCD groups compared with controls. A higher proportion of the SCD group, 11(25%) had hypergammaglobulinemia and 21(49%) had hypoalbuminemia (P<0.05). Plasma protein electrophoresis in SCD patients shows an intense colour at the gamma region which was not seen in control. There was a significant relationship between the patterns of serum protein electrophoresis and the frequency of crisis. Conclusions: Sickle cell disease crisis and other associated underlying conditions may be prevented early through assessment of serum protein profile, especially SPE. Hypergammaglobulinemia and hypoalbuminemia may be associated with frequent episode of crisis. Keywords: Serum protein, protein electrophoresis, sickle cell disease, Nigeria.
dc.identifier.citationSerum protein, protein electrophoresis, sickle cell disease, Nigeria.
dc.identifier.urihttps://doi.org/10.12681/healthresj.36006
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15968
dc.language.isoen
dc.publisherHealth & Research Journal
dc.relation.ispartofseriesVolume 10 Issue 4 October - December 2024; 243-35
dc.titleAssessment of serum protein profile in sickle cell disease
dc.typeArticle

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