Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats

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dc.contributor.authorKadir R.E.
dc.contributor.authorOjulari L.S.
dc.contributor.authorLawal I.A.
dc.contributor.authorSulu-Gambari L.
dc.contributor.authorHussein A/
dc.contributor.authorHamza A.
dc.contributor.authorAliagan I.A.
dc.contributor.authorOyewole L.A.
dc.date.accessioned2025-05-02T09:52:33Z
dc.date.available2025-05-02T09:52:33Z
dc.date.issued2022
dc.description.abstractOestrogens are steroid hormones that influence the growth, differentiation, and functioning of many target organs, including the male and female reproductive organs. Menopause, an important sign of aging in women is characterized by oestrogen depletion, which is associated with many menopausal problems. Oestrogen supplements that are mostly used are not readily safe and have been reported to cause serious health hazards Phytoestrogens are plant compounds that are essentially correspondent to oestradiol (17-β oestradiol) and can relate with oestrogen receptors to elevate and/or prohibit oestrogenic responses. This study therefore aimed at evaluating the possible therapeutic efficacy of Allium sativum and Allium cepa on oestrogenic activities of adult ovariectomised wistar rats. Adult Wistar rats were ovariectomized, then administered various doses of the extracts for 28days, then sacrificed and tissues harvested for analysis. Results shows Allium cepa and quercetin to increase endometrial thickness, increase neural cells in synaptophysin stained cells of hippocampus and dentate gyrus. A conclusion of Allium cepa possessing similar estrogenic properties as estradiol group in these ovariectomized rats was drawn, which can offer some ameliorative effects of estrogen deficiency.
dc.identifier.citation26. Kadir, R.E., Ojulari, L.S., Lawal, I.A., Sulu-Gambari, L, Hussein, A., Hamza, A., Aliagan, I.A., Oyewole, L.A. (2022): Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats. Anatomy Journal of Africa 11(1); 2062-2074. Published by Association of Anatomical Societies of Africa. Available online at https://www.ajol.info/index.php/aja/issue/view/20976
dc.identifier.issn2305-9478
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15799
dc.language.isoen
dc.publisherAssociation of Anatomical Societies of Africa
dc.relation.ispartofseriesVol 11, Issue 1; 2062-2074
dc.subjectOestrogen
dc.subjectOvariectomised
dc.subjectallium sativum
dc.subjectallium cepa
dc.titleComparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats
dc.typeArticle

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