Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats
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Date
2022
Authors
Kadir R.E.
Ojulari L.S.
Lawal I.A.
Sulu-Gambari L.
Hussein A/
Hamza A.
Aliagan I.A.
Oyewole L.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Association of Anatomical Societies of Africa
Abstract
Oestrogens are steroid hormones that influence the growth, differentiation, and functioning of
many target organs, including the male and female reproductive organs. Menopause, an
important sign of aging in women is characterized by oestrogen depletion, which is associated
with many menopausal problems. Oestrogen supplements that are mostly used are not readily
safe and have been reported to cause serious health hazards Phytoestrogens are plant
compounds that are essentially correspondent to oestradiol (17-β oestradiol) and can relate with
oestrogen receptors to elevate and/or prohibit oestrogenic responses. This study therefore aimed
at evaluating the possible therapeutic efficacy of Allium sativum and Allium cepa on oestrogenic
activities of adult ovariectomised wistar rats. Adult Wistar rats were ovariectomized, then
administered various doses of the extracts for 28days, then sacrificed and tissues harvested for
analysis. Results shows Allium cepa and quercetin to increase endometrial thickness, increase
neural cells in synaptophysin stained cells of hippocampus and dentate gyrus. A conclusion of
Allium cepa possessing similar estrogenic properties as estradiol group in these ovariectomized
rats was drawn, which can offer some ameliorative effects of estrogen deficiency.
Description
Keywords
Oestrogen, Ovariectomised, allium sativum, allium cepa
Citation
26. Kadir, R.E., Ojulari, L.S., Lawal, I.A., Sulu-Gambari, L, Hussein, A., Hamza, A., Aliagan, I.A., Oyewole, L.A. (2022): Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats. Anatomy Journal of Africa 11(1); 2062-2074. Published by Association of Anatomical Societies of Africa. Available online at https://www.ajol.info/index.php/aja/issue/view/20976