Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats.
No Thumbnail Available
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Research Journal of Health Sciences,
Abstract
Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
G.O. Omotoso, R.E. Kadir, S.F. Lewu, I.T. Gbadamosi, A.A. Akinlolu, G.O. Adunmo, R.M. Kolo, M.O. Lawal, M.O. Ameen
Abstract
Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum.
Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities.
Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO.
Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.
Description
Keywords
demyelination,, cuprizone, cerebellar damage,, Moringa oleifera,, oxidative enzymes
Citation
6(1):13-25.