Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats.

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dc.contributor.authorOmotoso, Gabriel Olaiya
dc.contributor.authorLewu, SF
dc.contributor.authorKadir, RE
dc.contributor.authorAdunmo, GO
dc.contributor.authorAmeen, MO
dc.date.accessioned2018-07-04T10:45:09Z
dc.date.available2018-07-04T10:45:09Z
dc.date.issued2018
dc.description.abstractMoringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats G.O. Omotoso, R.E. Kadir, S.F. Lewu, I.T. Gbadamosi, A.A. Akinlolu, G.O. Adunmo, R.M. Kolo, M.O. Lawal, M.O. Ameen Abstract Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.en_US
dc.identifier.citation6(1):13-25.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/800
dc.language.isoenen_US
dc.publisherResearch Journal of Health Sciences,en_US
dc.subjectdemyelination,en_US
dc.subjectcuprizoneen_US
dc.subjectcerebellar damage,en_US
dc.subjectMoringa oleifera,en_US
dc.subjectoxidative enzymesen_US
dc.titleMoringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats.en_US
dc.typeArticleen_US

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