PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL EFFECT OF SEEDS OF Monodora myristica ON SELECTED MICROORGANISMS
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Date
2020
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Abstract
The increase in the prevalence of effects of many synthetic antimicrobial agents and incidence of multiple drug
resistant microorganisms has spurred scientists on the research for plant-based antimicrobial of therapeutic
potentials. The Monodora myristica has been used in Nigeria traditionally as condiments and has been harnessed
as a therapeutic agent in the treatment of skin infection and dysentery. Aqueous, n-hexane and ethanolic extracts
of the seeds was screened for antimicrobial activity against pathogenic microorganisms implicated in causing
vagina infections. This finding showed that the efficacy of the extracts was concentration dependent. Aqueous,
ethanolic and N-hexane extract showed varying degree of inhibition with different magnitude against the test
isolates. Ethanolic extract showed highest activities against Candida albican, followed by Staphylococcus
aureus and Klebsiella pneumoniae with 21.5mm, 19.5 mm each respectively. The same patterns of of inhibition
was also observed in N-hexane extract. The antimicrobial effect of the two extracts were statistically not
significant. The extracts had minimum concentration that ranged between 150mg/ml and 200mg/ml. The
ethanolic extract showed more inhibitory effects compare to the aqueous and n- hexane extracts. The ethanolic
extract found to contain highest quantity of phytochemicals while aqueous extract has lowest amount of the
phytochemicals. It is therefore can be affirmed that Monodora myristica seed extracts could be exploited as
therapeutic agents to drug resistant microorganisms.
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Keywords
Monodora myristica, Therapeutic agents, Drug resistant microorganisms
Citation
Jimoh et al., 2020